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542 articles

October 202624

Clinical ResearchGeriatrics

Effects of Different Exercise Modalities on Interleukin-6, Brain-Derived Neurotrophic Factor, and Cognitive Function in Obese Older Women.

This randomized controlled trial compared control, aquatic aerobic exercise, aerobic dance, and combined aerobic and resistance exercise in obese women aged 65 years or older.

J Obes Metab SyndrOct 20, 2026Read summary
Clinical ResearchNeurology

Daily consumption of unsalted, skin-roasted peanuts beneficially affects regional brain insulin responsiveness in older adults: results of a longer-term randomized controlled trial.

This randomized, single-blind, controlled crossover trial examined whether peanut intake altered brain insulin responsiveness in 31 older adults (67 ± 4 years).

Food FunctOct 19, 2026Read summary
Clinical ResearchNeurology

Association of dietary choline intake with cognitive decline and related outcomes: a systematic review and dose-response meta-analysis of observational studies.

This systematic review and dose-response meta-analysis examined observational evidence on dietary choline intake and cognitive decline or related outcomes.

Food FunctOct 19, 2026Read summary
Clinical ResearchGeriatricsOpen access

Outdoor cycling competence and balance control in older adults - cross-sectional analysis of the BiPerAge trial.

This exploratory cross-sectional analysis used baseline data from a two-center randomized controlled trial to examine balance and outdoor cycling competence in 116 community-dwelling adults aged ≥ 65 years who made at…

BMC GeriatrOct 19, 2026Read summary
Clinical ResearchGeriatrics

Participant Characteristics Associated With Loneliness Reduction During a Digital Social Robot Intervention Among Older Adults Living Alone in Japan: Secondary Analysis of a Randomized Controlled Trial.

This secondary analysis of a randomized controlled trial examined whether participant characteristics were associated with changes in loneliness during a digital social robot intervention among community-dwelling older…

J Med Internet ResOct 16, 2026Read summary
Clinical ResearchRheumatology

Additive effects of active vitamin D3 or vitamin E administration on therapeutic lower-limb home exercise for knee osteoarthritis: A pilot prospective randomized controlled trial.

This pilot prospective randomized controlled trial assessed whether active vitamin D3 or vitamin E added benefit to home exercise in postmenopausal women with symptomatic knee osteoarthritis.

Medicine (Baltimore)Oct 16, 2026Read summary
Clinical ResearchGeriatrics

Effectiveness of traditional mind-body exercises on fall risk test scores and balance in older adults: A systematic review and meta-analysis.

This systematic review and meta-analysis pooled 31 randomized controlled trials involving 3,622 older adults to assess traditional mind-body exercises and fall-risk test scores and balance.

Medicine (Baltimore)Oct 16, 2026Read summary
Clinical ResearchGeriatrics

Planned Antihypertensive Deprescribing in Long-Term Care Residents: A Systematic Review of Randomized Evidence.

This systematic review synthesized randomized and cluster-randomized studies of planned antihypertensive deprescribing among long-term care residents.

Drugs AgingOct 16, 2026Read summary
Clinical ResearchOtolaryngology (ENT)

Cochlear Implantation and Cognitive Function in Adults: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis assessed cognitive test scores before and at least 6 months after cochlear implantation in adults with postlingual hearing loss.

Otol NeurotolOct 16, 2026Read summary
Clinical ResearchGeriatricsOpen access

Body weight following a multidomain lifestyle intervention in older adults at risk of dementia - A post-hoc analysis of the AgeWell.de-trial.

This post-hoc analysis of the cluster-randomized AgeWell.de trial examined body weight in 678 adults aged 60–77 years with overweight or obesity and at risk for dementia.

BMC GeriatrOct 15, 2026Read summary
Clinical ResearchGeriatrics

Vegetarian and Vegan Diets and the Risk of Hip Fracture in Adults: A Systematic Review and Meta-analysis.

This systematic review and meta-analysis assessed hip-fracture risk in adults following vegetarian or vegan diets compared with meat-eaters. Four cohort studies involving 529 672 participants were included.

Nutr RevOct 14, 2026Read summary
Clinical ResearchGeriatrics

Feasibility of Online and On-Site Physical Activity Delivery Among Older Adults: Mixed Methods Pilot Randomized Controlled Trial.

This unblinded, site-cluster-randomized mixed methods pilot trial assessed the feasibility of a 26-week Otago physical activity program delivered online or in person to community-dwelling adults aged 60 years or older…

JMIR Form ResOct 13, 2026Read summary
Clinical ResearchGeriatrics

Effects of aquatic and land-based resistance training on hip bone health in overweight older women: A 32-week randomized controlled trial.

This secondary analysis of a six-arm randomized controlled trial compared supervised aquatic and land-based elastic resistance training with control in 98 older women with overweight.

Arch Gerontol GeriatrOct 13, 2026Read summary
Clinical ResearchGeriatrics

Negotiating Care Over Time: A Systematic Review of Alzheimer's Disease Caregiving Through a Life Course Approach.

This systematic review examined sociological research published between 2004 and 2024 on family caregiving for people with Alzheimer’s disease, focusing on how caregiving intersects with caregivers’ life trajectories…

Sociol Health IllnOct 11, 2026Read summary
Clinical ResearchGeriatrics

Association Between a Hybrid Video-Guided Multicomponent Exercise Program With Staff Assistance and Free-Living Gait in Older Adults With Knee and Low Back Pain: Secondary Analysis of a Randomized Controlled Trial.

This secondary analysis of a randomized controlled trial examined whether a 12-week hybrid exercise program affected free-living walking in 59 community-dwelling adults aged 65 years or older with mild to moderate knee…

JMIR AgingOct 8, 2026Read summary
Clinical ResearchAnesthesiologyOpen access

Effect of Anterior Quadratus Lumborum Block at the Lateral Supra-Arcuate Ligament Combined with Esketamine on the Quality of Postoperative Recovery After Laparoscopic Radical Surgery for Elderly Patients with Colorectal Cancer: A Randomized Controlled Trial.

This single-centre, randomized, placebo-controlled trial evaluated anterior quadratus lumborum block at the lateral supra-arcuate ligament (QLB-LSAL), low-dose esketamine, or their combination in patients aged 60 years…

Drug Des Devel TherOct 8, 2026Read summary
Clinical ResearchGeriatrics

Adverse childhood experiences, cognitive outcomes, and frailty in older adults: a systematic review and meta-analysis.

This systematic review and meta-analysis examined associations between adverse childhood experiences (ACEs) and frailty or cognitive outcomes in middle-aged and older adults.

GerontologistOct 8, 2026Read summary
Clinical ResearchGeriatrics

The effect of balance training on cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis.

This systematic review and meta-analysis examined balance training and cognitive function in adults aged 60 years or older, with and without cognitive impairment.

Arch Gerontol GeriatrOct 8, 2026Read summary
Clinical ResearchGeneral Surgery

Preoperative pathways in adults with multiple long-term conditions undergoing major surgery: a systematic review.

This systematic review examined preoperative interventions, pathways and protocols for adults with multiple long-term conditions (MLTCs) undergoing major surgery.

BMJ OpenOct 7, 2026Read summary
Clinical ResearchAnesthesiology

Effects of remimazolam versus propofol on cerebral oxygenation in elderly patients undergoing prone spine surgery: study protocol for a randomised controlled trial.

This article describes the protocol for a prospective, single-centre randomised controlled trial comparing remimazolam with propofol-based total intravenous anaesthesia in elderly patients undergoing elective thoracic…

BMJ OpenOct 7, 2026Read summary
Clinical ResearchGeriatrics

Dose- and modality-specific effects of exercise on BDNF and depression in middle-aged and older adults with mild cognitive impairment: A Bayesian network meta-analysis.

This Bayesian network dose-response meta-analysis examined randomized controlled trials of exercise in adults aged 50 years or older with mild cognitive impairment (MCI), assessing peripheral brain-derived neurotrophic…

PLoS OneOct 7, 2026Read summary
Clinical ResearchInfectious Diseases

Immunogenicity and Safety of the Adjuvanted Respiratory Syncytial Virus Prefusion F Protein-Based Vaccine When Co-administered With the Adjuvanted Recombinant Herpes Zoster Subunit Vaccine in Adults ≥ 50 Years of Age.

This phase III, open-label, randomised trial compared co-administration of adjuvanted RSVPreF3 and recombinant zoster vaccine (RZV) with administration one month apart in adults aged ≥50 years.

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchGeriatrics

Immunogenicity and Safety of Co-administration of Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine With 20-Valent Pneumococcal Conjugate Vaccine in Adults Aged ≥60 Years: A Randomized, Non-inferiority Trial.

This phase III, open-label, randomized non-inferiority trial compared concomitant versus one-month-apart administration of adjuvanted RSV prefusion F protein vaccine (RSVPreF3) and 20-valent pneumococcal conjugate…

Clin Infect DisOct 7, 2026Read summary
Clinical ResearchPsychiatry

Effectiveness of psychosocial interventions addressing informal caregivers' mental health: an umbrella systematic review with 26,481 participants.

This umbrella systematic review and random-effects meta-analysis assessed psychosocial interventions for the mental health of informal caregivers, grouped by care recipients’ clinical conditions.

Clin Psychol RevOct 7, 2026Read summary

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