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1357 articles
October 202624
Crisis Interventions for Children and Adolescents with Depression and Suicidality: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined crisis services for children and adolescents experiencing acute mental health crises, including severe depression, suicidal ideation, self-harm, and suicidal behaviour.
The association between e-cigarette use and dyslipidemia: A systematic review and meta-analysis of observational studies.
This systematic review and meta-analysis examined observational evidence on exclusive e-cigarette use and blood lipids in adults. Seven studies from four countries included 25,690 participants.
Imaging Features and Prognosis of Anti‑Sez6l2 Encephalitis: A Longitudinal Cohort Study and Literature Review.
This longitudinal cohort study and systematic review examined clinical features, multimodal imaging, and treatment response in anti-Sez6l2 encephalitis.
Impact of age and frailty on the effect of a multimodal individualized long-term intervention after stroke: the last-long trial.
This single-blinded, multicentre randomized controlled trial examined whether age or frailty modified response to a stroke coordinator-led, individualized community intervention.
Effects of Virtual Reality Based Aerobic Exercise on Pulmonary Function and Cardiopulmonary Fitness in Parkinson's Disease: A Pilot Randomized Controlled Trial.
This single-blinded pilot randomized controlled trial evaluated Wii Fit Plus aerobic exercise in 30 people with Parkinson’s disease (Hoehn and Yahr stages II–III) and respiratory impairment.
Measurement Properties of Hand-Held Dynamometry for Ankle Strength Assessment: A COSMIN-Based Systematic Review and Meta-Analysis.
This COSMIN-based systematic review and meta-analysis assessed handheld dynamometry (HHD) for measuring isometric ankle muscle strength in healthy individuals.
Reduced-dose alternate-day oral iron supplementation in women with iron deficiency: a randomized controlled trial.
This 42-day, randomized, parallel-group active-controlled trial compared two oral iron regimens in 66 women aged 18–50 years with iron deficiency (serum ferritin < 30 ng/mL).
Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy versus standard of care for locally advanced rectal cancer (UNION): a prespecified interim analysis of a multicentre, open-label, randomised, phase 3 trial.
UNION was a multicentre, open-label, randomised phase 3 trial at nine hospitals in China comparing neoadjuvant short-course radiotherapy followed by camrelizumab plus CAPOX with long-course chemoradiotherapy followed by…
Prognostic associations between patient-reported outcomes and progression-free and overall survival in advanced gastric or gastroesophageal junction adenocarcinoma with PD-L1 TAP score ≥ 5%: results from the RATIONALE-305 trial.
This analysis of the randomised RATIONALE-305 trial examined whether longitudinal patient-reported outcomes (PROs) were associated with progression-free survival (PFS) and overall survival (OS) in patients with advanced…
A randomized study comparing plant sterol- and soluble fiber-enriched soymilk with plain soymilk in adults with elevated LDL cholesterol.
This randomized controlled trial compared plant sterol- and soluble fiber-enriched soymilk with plain soymilk in 242 adults with hypercholesterolemia, untreated or on stable lipid-lowering therapy.
Uniportal versus multiportal robotic-assisted thoracic surgery for anatomical pulmonary resection: a systematic review and meta-analysis of perioperative recovery and surgical quality.
This systematic review and meta-analysis compared uniportal/single-port with multiportal robotic-assisted thoracic surgery for anatomical pulmonary resection.
Efficacy and safety of GLP-1 receptor agonists for antipsychotic-related overweight and metabolic dysregulation: a systematic review and meta-analysis.
This systematic review and meta-analysis pooled randomized controlled trials of GLP-1 receptor agonists in adults receiving antipsychotic treatment for overweight or metabolic dysregulation.
Stereotactic body radiation therapy for pancreatic cancer: evaluating its efficacy, safety, and future prospects: systematic review.
This systematic narrative review assessed stereotactic body radiation therapy (SBRT) for locally advanced pancreatic cancer, including patients unsuitable for surgery.
Effect of Rapid Rollover on Pneumothorax Rate After Percutaneous CT-Guided Lung Biopsy: A Multisite Randomized Controlled Trial Within a Single Health System.
This prospective, multisite randomized controlled trial evaluated rapid rollover after CT-guided lung biopsy using an anterior or lateral approach.
Cine Magnetic Resonance Imaging for Assessing Chest Wall Invasion in Lung Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated cine MRI for detecting chest wall invasion in lung cancer, using surgical and histopathologic findings as the reference standard.
Influence of capsular tension ring implantation on dynamic in vivo capsular apposition and intraocular lens behavior in highly myopic eyes.
This prospective randomized clinical trial assessed whether capsular tension ring (CTR) implantation affects capsular apposition and intraocular lens (IOL) behavior after cataract surgery in highly myopic eyes.
Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial.
RISE UP was a phase 3, double-blind, global, randomised, placebo-controlled trial conducted at 69 sites in 15 countries. It evaluated twice-daily mitapivat in patients older than 16 years with sickle cell disease…
Timing of diverting ileostomy closure after low anterior resection for rectal cancer: a GRADE-assessed systematic review and meta-analysis of early and delayed closure.
This GRADE-assessed systematic review and meta-analysis compared early with delayed diverting ileostomy closure after low anterior resection for rectal cancer.
Evaluating the effectiveness of the eHealth-faciLitated SMILe-integrated care model on treatment burden, quality of life and graft-versus-host disease after allogeneic stem cell transplantation: results of two European randomized controlled implementation studies.
Two multicentre, hybrid effectiveness-implementation randomised controlled trials at European allogeneic stem cell transplantation (alloSCT) centres evaluated SMILe-ICM, an eHealth-supported, advanced practice nurse-led…
Combination therapy of carbon dioxide laser with topical halometason cream and 308 nm excimer laser for the treatment of vitiligo: an optimized combined treatment protocol.
This randomized controlled trial evaluated fractional CO₂ laser plus topical halometasone cream and 308-nm excimer lamp therapy for refractory non-segmental vitiligo, compared with excimer therapy, a topical calcineurin…
Preserved anabolic skeletal muscle capacity in response to exercise and protein intake after critical illness.
This clinical trial compared skeletal muscle responses to resistance exercise plus protein intake in 20 intensive care unit (ICU) survivors, assessed 3 to 6 months after discharge, and 20 age- and sex-matched controls.
Digital Therapeutic Interventions for Suicide Prevention: A Systematic Review and Meta-Analysis of Their Effectiveness in Reducing Suicidal Ideation and Suicide Attempts.
This systematic review and meta-analysis synthesised randomized clinical trials of digital interventions for suicide prevention. Seventeen studies (N = 5.089) were included.
Informal Caregiver-Observed Fall Risk Indicators and Caregiver Responses to Prevent Falls Among Community-Dwelling Older People: A Systematic Review.
This systematic review synthesized 16 studies of informal caregivers’ observations of fall-risk indicators and their preventive responses among community-dwelling older people.
Mapping the prevalence of Epstein-Barr virus and multiple sclerosis in Middle East and North Africa: a systematic review and meta-analysis.
This systematic review and meta-analysis mapped published estimates of multiple sclerosis (MS) prevalence and Epstein-Barr virus (EBV) seroprevalence in Middle East and North Africa populations.
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