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2000 articles
September 202624
Selinexor combined with R-CHOP achieved a high response rate in newly diagnosed double/triple-hit lymphoma.
This phase II clinical trial evaluated the combination of selinexor with R-CHOP in 13 patients with newly diagnosed double-hit and triple-hit lymphoma.
Testosterone monitoring and supplementation in patients with intermediate- or high-risk prostate cancer treated with 6-36 months of androgen deprivation therapy and radiotherapy: a systematic literature review.
This systematic literature review examined testosterone monitoring, recovery, and replacement therapy in patients with intermediate- or high-risk localised prostate cancer treated with androgen deprivation therapy (ADT)…
Neoadjuvant chemoimmunotherapy with afatinib for locally advanced head and neck squamous cell carcinoma (neoCHANCE-2): an open-label, single-arm, phase 2 study.
This phase 2, single-arm trial evaluated neoadjuvant chemoimmunotherapy with afatinib in 40 patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC).
Frailty and mortality in patients with cancer: A systematic review and meta-analysis of 191 observational studies.
This systematic review and meta-analysis examined observational evidence on frailty and mortality among adults with cancer.
OPEN: optimising patient experience in head and neck radiotherapy, a phase 3 randomised control trial comparing open versus closed face masks.
This phase 3 randomised trial compared three immobilisation approaches in non-claustrophobic patients receiving radical head and neck radiotherapy: a closed 5-point mask without surface-guided radiotherapy (SGRT), and…
Margin positivity and re-excision after breast-conserving surgery following neoadjuvant chemotherapy: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis examined tumour-on-ink margin positivity and re-excision after breast-conserving surgery (BCS) following neoadjuvant chemotherapy (NACT).
A systematic review of international/national guidelines for the management of nasopharyngeal carcinoma: Convergence and divergence of recommendations.
This systematic review analyzed 26 clinical practice guidelines for nasopharyngeal carcinoma (NPC) published from January 2000 to November 2025.
Tambotatug Pelitecan in Small-Cell Lung Cancer after Platinum-Based Therapy.
This phase 3, multicenter, open-label randomized trial compared tambotatug pelitecan with topotecan in patients whose small-cell lung cancer had progressed after first-line platinum-based therapy.
Steroidogenesis inhibitor ODM-209 for metastatic castration-resistant prostate cancer and advanced breast cancer: Results from the first-in-human STESIDES study.
The multicentre, first-in-human phase 1 STESIDES dose-finding study evaluated oral ODM-209, a CYP11A1 inhibitor, in adults with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC) and advanced…
DPYD c.85 T > C, DPYD c.496 A>G, and DPYD c.2194 G>A and severe toxicity to fluoropyrimidines in PREPARE and Alpe-DPD trials. An original study and meta-analysis.
This meta-analysis evaluated the impact of DPYD variants on severe toxicity from fluoropyrimidines in 17,485 patients across multiple studies, including the PREPARE and Alpe-DPD trials.
Trastuzumab Botidotin Versus Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2-Positive Advanced Breast Cancer: A Phase III, Open-Label, Randomized Controlled Trial.
This phase III, open-label, multicenter randomized trial compared trastuzumab botidotin with trastuzumab emtansine in adults with HER2-positive unresectable or metastatic breast cancer previously treated with…
Cost-Effectiveness of Electronic Patient-Reported Outcome Measure Interventions in Cancer: Systematic Review and Parameter Extraction for Economic Modeling.
This systematic review evaluated the cost-effectiveness of electronic patient-reported outcome measures (ePROM) in cancer care, analyzing 34 publications from 27 studies.
Comparative oncological efficacy of chemotherapy, cytoreductive surgery with or without HIPEC in recurrent ovarian cancer: A network meta-analysis.
This systematic review and network meta-analysis compared chemotherapy (CHT), secondary cytoreductive surgery (SCS), and SCS with hyperthermic intraperitoneal chemotherapy (HIPEC) for platinum-sensitive recurrent…
Primary Hepatic Lymphoma with Hepatocellular Carcinoma: A Case Report.
A patient with hepatocellular carcinoma (HCC) presented with atypical imaging findings that led to the discovery of primary hepatic lymphoma (PHL).
Short course versus conventional interventional radiotherapy (brachytherapy) regimen in locally advanced cervical cancer: A randomized clinical trial.
This randomized clinical trial compared a one-week versus conventional three-week high-dose-rate interventional radiotherapy (brachytherapy) schedule in patients with stage IB2–IVA cervical cancer receiving definitive…
Oncological impact of adjuvant chemotherapy after rectal cancer excision in the era of FOLFIRINOX-based TNT: A pooled post-hoc analysis of GRECCAR4-PRODIGE23.
This multicenter randomized controlled trial analyzed the impact of adjuvant chemotherapy (AC) on oncological outcomes in patients with locally advanced rectal cancer (LARC) following total neoadjuvant therapy (TNT) or…
Uterine Sarcomas With KDM2B Fusion: Clinicopathological Analysis of Three Cases Supporting a Novel BCOR-Altered Entity.
The report describes three uterine sarcomas with KDM2B fusions involving EPC1, EPC2, or CREBBP. Their morphology varied: one was purely spindle-cell, another combined spindle and round cells, and the third showed a…
Economic advantage of daratumumab, bortezomib, lenalidomide, and dexamethasone vs bortezomib, lenalidomide, and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: A cost-per-responder evaluation.
This phase III comparative study evaluated the economic impact of daratumumab, bortezomib, lenalidomide, and dexamethasone (DVRd) versus bortezomib, lenalidomide, and dexamethasone (VRd) in transplant-ineligible or…
70-gene signature MammaPrint for early-stage HR-positive, HER2-negative breast cancer: Outcome in the MINDACT trial for key clinical-pathological high-risk subgroups.
The MINDACT trial explored the role of the 70-gene signature (MammaPrint) in patients over 50 with early-stage HR-positive, HER2-negative breast cancer.
Quality of life in patients with RAS wild-type metastatic colorectal cancer treated mFOLFOXIRI + panitumumab versus FOLFOXIRI: A prespecified secondary analysis of the phase II VOLFI AIO-KRK 0109 trial.
This phase II randomized controlled trial evaluated health-related quality of life (HRQoL) in 105 patients with RAS wild-type metastatic colorectal cancer receiving mFOLFOXIRI + panitumumab versus FOLFOXIRI.
Effects of Esketamine on Postoperative Hospital Anxiety and Depression Scale Scores in Patients Undergoing Laparoscopic Radical Resection for Colorectal Cancer.
This randomized controlled trial examined the impact of intravenous esketamine on postoperative anxiety and depression in patients undergoing laparoscopic radical resection for colorectal cancer.
Successful treatment of massive stage IIIB cervical cancer with a spindle cell component: A case report.
A 33-year-old woman presented with a massive cervical mass measuring 14 × 13 × 13 cm, accompanied by intermittent vaginal bleeding and progressive fatigue.
Patient-reported symptom monitoring in patients with lung cancer (SYMPRO-Lung trial): long-term, post-hoc survival results of a multicentre, stepped-wedged, cluster-randomised clinical trial.
The SYMPRO-Lung trial, a multicentre, stepped-wedged, cluster-randomised clinical trial, evaluated the impact of patient-reported outcome (PRO) symptom monitoring on survival in 446 patients with stage I-IV lung cancer.
Quality of life and pain-response after stereotactic ablative radiotherapy of oligometastatic bone metastases in the phase 2 BONY-M trial.
This phase 2 multicentre trial evaluated longitudinal health-related quality of life (HRQoL) and pain response after stereotactic ablative radiotherapy (SABR) for bone metastases in patients with oligometastatic…
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