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2000 articles
September 202624
Induction FLOT Chemotherapy Prior to Neoadjuvant Chemoradiotherapy in the Treatment of Lower Esophageal and Proximal Gastric Adenocarcinoma: A Phase II, Single-Arm Clinical Trial.
This Phase II, single-arm clinical trial evaluated the effectiveness of induction FLOT chemotherapy followed by neoadjuvant chemoradiotherapy in patients with resectable distal esophageal and proximal gastric…
Camrelizumab, Apatinib, and Radiotherapy in Locally Advanced, Unresectable Hepatocellular Carcinoma: A Phase II Study.
This phase II trial evaluated the combination of camrelizumab, apatinib, and intensity-modulated radiotherapy in 44 patients with locally advanced, unresectable hepatocellular carcinoma (HCC).
The First-in-Human ENCIT01 Trial Comparing Second- versus Third-Generation L1CAM-specific CAR T Cells in Patients with Primary Refractory or Relapsed Neuroblastoma.
The ENCIT-01 trial was a Phase I clinical study evaluating L1CAM-specific CAR T cells in 36 children with relapsed or refractory neuroblastoma. The trial compared second- and third-generation CAR constructs.
Tumoral and Systemic Immune Correlates of Response to Concurrent Pembrolizumab and Chemoradiotherapy in Patients with Resected High-Risk Head and Neck Squamous Cell Carcinoma.
This phase I clinical trial evaluated the safety and immune correlates of adjuvant pembrolizumab combined with chemoradiotherapy (CRT) in 34 patients with high-risk, HPV-negative head and neck squamous cell carcinoma.
Two-year outcomes following PSMA PET and MRI guided prostate SABR with simultaneous focal boost: a brief report from the ARGOS-CLIMBER phase 1/2 trial.
This brief report presents two-year outcomes from ARGOS-CLIMBER, a phase 1/2 clinical trial of PSMA PET- and MRI-guided stereotactic ablative radiotherapy (SABR) with simultaneous boosts to intraprostatic and nodal…
Resection of a symptomatic complex anterior mediastinal teratoma via sternotomy.
A patient presented with a large anterior mediastinal teratoma measuring 11 × 10 × 10 cm, causing significant compression of the right atrium, right ventricle, superior vena cava, and aorta, along with perforation into…
Immune Checkpoint Inhibitor-Associated Hemophagocytic Lymphohistiocytosis: Clinical Presentation and Outcomes in Three Patients.
Three patients receiving immune checkpoint inhibitors presented with diverse clinical symptoms indicative of systemic inflammation.
Talimogene Laherparepvec Response in Recurrent Melanoma During Corticosteroid Replacement for Immune Checkpoint Inhibitor-Induced Adrenal Insufficiency: A Case Report.
A 78-year-old man with recurrent in-transit melanoma of the scalp developed secondary adrenal insufficiency after pembrolizumab therapy, necessitating chronic hydrocortisone replacement.
A Phase II Feasibility Study Combining Pembrolizumab and Metformin in Patients with Metastatic Head and Neck Cancer.
This Phase II randomized controlled trial evaluated the combination of metformin and pembrolizumab in patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC).
Early deep response to cilta-cel as 2nd CAR T-Cell therapy after CELMoD-based bridging for advanced multiple myeloma.
A 58-year-old male with high-risk IgA kappa multiple myeloma, previously treated with multiple therapies, received idecabtagene vicleucel as sixth-line treatment, achieving a deep response for about one year.
Pathological response after neoadjuvant therapy in soft tissue sarcoma: A systematic review of its association with local recurrence, distant metastasis, and survival.
This systematic review assessed whether pathological response after neoadjuvant treatment predicts oncological outcomes in adults with localized soft tissue sarcoma treated with surgery.
Effect of neoadjuvant androgen deprivation therapy on prostate and tumor morphology prior to MRI-guided transurethral ultrasound ablation of prostate cancer.
This prospective, single-arm pilot study evaluated the effects of 3-month neoadjuvant androgen deprivation therapy (nADT) with degarelix on prostate and tumor morphology in 15 treatment-naïve patients with…
Outcomes of stereotactic radiosurgery for spine multiple myeloma-a systematic review.
This systematic review assessed the outcomes of stereotactic radiosurgery (SRS) for spinal multiple myeloma, analyzing three retrospective studies involving 133 patients.
Rituximab Versus Watchful Waiting for Asymptomatic Advanced-Stage Low-Tumor-Burden Follicular Lymphoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared rituximab monotherapy with watchful waiting (WW) in adults with asymptomatic, advanced-stage, low-tumor-burden follicular lymphoma.
Feasibility and efficacy of an emotion-based online intervention for the treatment of anxiety and depression in people with cancer - Results of a randomized controlled trial.
This randomized controlled trial assessed the feasibility and efficacy of a 10-week emotion-based online psycho-oncological self-help intervention (epos) for adults with cancer who were receiving treatment or aftercare.
Intravoxel incoherent motion (IVIM) MRI for predicting IDH mutation status in adult diffuse glioma: a systematic review and diagnostic test accuracy meta-analysis.
This systematic review and diagnostic test accuracy meta-analysis assessed IVIM MRI parameters for predicting IDH mutation status in adults with diffuse glioma.
Comparative efficacy and safety of first, second, and third-generation EGFR tyrosine kinase inhibitors in treatment-naïve EGFR-mutant advanced non-small cell lung cancer: a systematic review and network meta-analysis of randomized controlled trials.
This systematic review and network meta-analysis evaluated the efficacy and safety of first, second, and third-generation EGFR tyrosine kinase inhibitors (TKIs) in treatment-naïve patients with EGFR-mutant advanced…
First-in-human phase I study of DT-9081, a selective EP4 receptor antagonist, in advanced solid tumors.
This open-label, multicentre, first-in-human phase I dose-escalation study evaluated oral DT-9081, a selective EP4 receptor antagonist, in 29 patients with advanced solid tumors refractory to standard therapies.
Health Literacy and Capecitabine Adherence in a Remote Monitoring Pilot Trial for Breast Cancer: Post Hoc Exploratory Analysis.
This post hoc exploratory analysis of a randomized controlled trial examined the relationship between health literacy and capecitabine adherence in women with breast cancer.
First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis.
This preliminary clinical trial evaluated first-line fecal microbiota transplantation (FMT) for immune checkpoint inhibitor-mediated diarrhea and colitis (IMDC), using multi-omics profiling.
Patient-clinician symptom agreement before and after radiotherapy for prostate cancer: results from the randomized HYPO-RT-PC study.
This sub-study of the randomized HYPO-RT-PC trial assessed agreement between patient- and clinician-reported urinary, bowel, and sexual symptoms in 1,180 men receiving conventional or ultra-hypofractionated radiotherapy…
Robotic surgery for gastric gastrointestinal stromal tumors: a systematic review.
This systematic review evaluated robotic surgery for gastric gastrointestinal stromal tumors (GISTs) across 23 studies, including six comparative cohorts.
RENOIR phase 3 rituximab-lenalidomide vs rituximab as maintenance treatment in relapsed/refractory follicular lymphoma.
The RENOIR phase 3 trial evaluated rituximab plus lenalidomide (R2) versus rituximab alone (R) as maintenance therapy in older patients with relapsed/refractory follicular lymphoma.
Radium-223 decreases PD-L1 expression in bone metastases: A study with [ 89 Zr]Zr-atezolizumab PET and immunohistological correlation.
This prospective, multicenter clinical study examined immune changes during standard-of-care radium-223 treatment in 28 patients with metastatic castration-resistant prostate cancer and predominantly bone metastases.
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