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2000 articles
September 202624
A phase 2 pharmacokinetic and pharmacodynamic dose-finding study of oral NEPA for chemotherapy-induced nausea and vomiting in pediatric patients with cancer.
This phase 2 randomized controlled trial assessed the pharmacokinetics, pharmacodynamics, efficacy, and safety of oral netupitant combined with oral palonosetron (NEPA) in pediatric patients (< 18 years) undergoing…
Epidermoid Cyst of the Ureter Mimicking Recurrent Urothelial Carcinoma: A Case Report and Brief Literature Review.
A 79-year-old man with a history of high-grade papillary urothelial carcinoma presented with a proximal right ureteral filling defect on CT scan, raising suspicion for tumor recurrence.
The "Scintigraphic Flip": A Visual Warning Sign of Impending Hematologic Toxicity.
A 55-year-old man with metastatic castration-resistant prostate cancer developed increased diffuse marrow uptake and reduced salivary-gland and liver activity on imaging after his second cycle of ¹⁷⁷Lu-PSMA therapy.
Oncologic and perioperative outcomes of laparoscopic versus open gastrectomy for T4a gastric cancer: A systematic review and meta-analysis.
This systematic review and meta-analysis compared laparoscopic with open gastrectomy for T4a gastric cancer, including evidence from 13 studies: 2 randomised trials and 11 non-randomised cohorts.
Cancer co-medication quality in older patients with polypharmacy: A large randomized trial testing a medication review versus usual care.
This multicentre, single-blinded randomised controlled trial tested a pharmacist-led medication review using the FORTA list versus usual care in patients aged ≥ 65 years with common cancers and polypharmacy at ten…
Management of immune-related cutaneous adverse events associated with immune checkpoint inhibitors in patients with cancer: an evidence summary.
This systematic review synthesizes evidence on managing immune-related cutaneous adverse events (ircAEs) in cancer patients receiving immune checkpoint inhibitors (ICIs).
Acupuncture for chemotherapy-induced nausea and vomiting: An umbrella review of systematic reviews.
This umbrella review assessed invasive acupuncture for chemotherapy-induced nausea and vomiting (CINV), synthesizing existing systematic reviews and meta-analyses and conducting a renewed meta-analysis of primary…
Reduced oxaliplatin exposure in gastrointestinal cancers: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis compared reduced oxaliplatin exposure (ROE) with standard-duration oxaliplatin-based therapy in gastrointestinal cancers.
Five-Year Follow-Up of the Phase III ASCOT Trial of Adjuvant S-1 After Resection for Biliary Tract Cancer.
This prespecified five-year follow-up of the multicenter, open-label, randomized phase III ASCOT trial assessed adjuvant S-1 versus observation after resection for biliary tract cancer in 440 patients in Japan.
Acceptance and perceived efficacy of intraoral versus extraoral photobiomodulation for oral mucositis prevention in pediatric patients.
This randomized controlled trial evaluated the acceptance and perceived efficacy of intraoral (IO) versus extraoral (EO) photobiomodulation therapy for preventing oral mucositis in 32 pediatric oncology patients.
Meta-analysis of NPC2-mediated cholesterol transport in human cancers as a prognostic biomarker with therapeutic implications.
This meta-analysis evaluated the prognostic significance of NPC2 expression in tumor tissues from 2,097 cancer patients. The study found that elevated NPC2 expression was significantly associated with worse overall…
Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo-controlled trial.
The EVITA trial, a phase 2 randomized controlled trial, evaluated oral vitamin C supplementation in 109 adults with clonal cytopenia of undetermined significance or lower-risk myeloid malignancies.
Anti-OJ antibody-positive anti-synthetase syndrome associated with hepatocellular carcinoma.
A man in his 70s with hepatocellular carcinoma presented with progressive proximal muscle weakness and dropped head syndrome.
Durable remission of sinonasal mucosal melanoma despite early ICI discontinuation and risankizumab treatment for irAEs.
A patient with metastatic sinonasal mucosal melanoma experienced a remarkable and durable response to immune checkpoint inhibitors despite early treatment discontinuation due to severe immune-related adverse events.
Neoplastic mimicry of arterial disease.
Two patients presented with vascular symptoms and were admitted to a vascular surgery unit. Upon further investigation, the underlying cause of their symptoms was determined to be neoplastic rather than vascular in…
A workbook- and audio-administered, telephone-guided, low-intensity cognitive behavioural therapy intervention (EJDeR) for parents of persons treated for cancer during childhood: protocol for the CHANGE-pilot randomised controlled trial.
The CHANGE-pilot trial is a parallel-group, two-arm, pilot randomized controlled trial assessing the feasibility of the EJDeR intervention, a low-intensity cognitive behavioural therapy for parents of children treated…
Where do delays occur? A systematic review of the barriers to early breast cancer diagnosis across South Africa's health system.
This systematic review examined barriers to early breast cancer diagnosis in South Africa, where the 5-year survival rate is only 40%.
CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT-a systematic review.
This systematic review evaluated the clinical utility of CT-derived myocardial extracellular volume (ECV) across various cardiovascular diseases.
Transanal tube for the prevention of anastomotic leakage in rectal cancer surgery.
This systematic review and meta-analysis evaluated the effectiveness of a transanal tube in preventing anastomotic leakage in rectal cancer surgery, involving 1318 participants across four randomized controlled trials.
Recovery of ovarian function after chemotherapy in premenopausal women with breast cancer: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated ovarian function recovery post-chemotherapy in 10,216 premenopausal women with breast cancer.
Severe, reversible alectinib-induced acute kidney injury requiring dialysis in an elderly patient with metastatic non-small cell lung cancer.
An elderly patient with advanced ALK-rearranged non-small cell lung cancer developed severe acute kidney injury requiring dialysis shortly after starting alectinib.
Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer: A Randomized Clinical Trial.
This phase-3 randomized clinical trial compared stereotactic body radiotherapy (SBRT) to moderately hypofractionated intensity-modulated radiation therapy (MH-IMRT) in patients with localized intermediate-risk prostate…
Neoadjuvant antibody-drug conjugates for early-stage breast cancer: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis assessed neoadjuvant antibody-drug conjugates (ADCs), alone or in combination, in early-stage breast cancer.
Ultra-processed food consumption and risk of multiple chronic diseases among 8,819,894 adults from 51 prospective cohorts: a dose-response meta-analysis.
This meta-analysis examined the relationship between ultra-processed food (UPF) consumption and the risk of chronic diseases in 8,819,894 adults across 51 prospective cohorts.
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