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2000 articles
September 202624
Osteosarcoma of the Maxilla: Rare Contralateral Cervical Lymph Node Metastasis.
A patient with osteosarcoma of the maxilla presented with contralateral cervical lymph node metastasis following surgical intervention.
Expanded antigen-specific donor regulatory T cells for GVHD prevention.
This phase 1 clinical trial evaluated the safety and preliminary efficacy of expanded minor histocompatibility antigen (mHAg)-specific donor regulatory T cells (Treg) for preventing graft-versus-host disease (GVHD) in…
Population pharmacokinetic analysis of pirtobrutinib, a non-covalent BTK inhibitor, in patients with hematological malignancies from the Phase 1/2 BRUIN study.
This population pharmacokinetic analysis evaluated pirtobrutinib, a non-covalent BTK inhibitor, in 595 patients with hematological malignancies from the Phase 1/2 BRUIN study.
Structured exercise interventions and survival outcomes in patients with cancer: systematic review and meta-analysis of randomised controlled trials.
This systematic review and meta-analysis evaluated the impact of structured exercise interventions on survival outcomes in cancer patients.
Giant Well-Differentiated Liposarcoma of the Spermatic Cord Associated With Inguinal Hernia: Clinical Insights From a Case Report.
An 87-year-old man presented with a progressively enlarging, painless mass in the left inguinoscrotal region, which impaired mobility.
A rare ATM variant in a Colombian family with chorea-ataxia syndrome: implications for an early diagnosis.
A 39-year-old man presented with progressive ataxia, chorea, and telangiectasias, alongside two siblings with similar symptoms. Genetic testing revealed compound heterozygous variants in the ATM gene.
Femoral Neck System and Cement Augmentation for Temporizing a Pathologic Hip Fracture in Osteosarcoma: A Case Report.
A 17-year-old boy with primary osteosarcoma presented with a pathologic hip fracture. He underwent cement-augmented internal fixation using a femoral neck system, which facilitated pain management and allowed for the…
Molecular imaging tracers targeting c-MET: a systematic review of preclinical evidence and clinical translation.
This PRISMA-guided systematic review assessed radioactive and fluorescent tracers targeting c-MET in preclinical and clinical studies.
Colonic metastasis from anaplastic thyroid carcinoma: The value of [ 18 F]FDG PET/CT in an unusual presentation.
A patient with anaplastic thyroid carcinoma containing a papillary component and a BRAF V600E mutation had locoregional invasion and residual disease detected after surgery. The patient received radiotherapy.
Vorinostat for graft-versus-host disease prevention in pediatric and young adult patients with hematologic malignancies.
This prospective, single-arm, multicenter phase I/II trial evaluated vorinostat added to standard GVHD prophylaxis in patients aged 3–39 years undergoing allogeneic hematopoietic cell transplantation from matched or…
AdvanTIG-105: a phase I/Ib dose-expansion study of ociperlimab plus tislelizumab with or without chemotherapy in metastatic non-small cell lung cancer and extensive-stage small cell lung cancer.
The AdvanTIG-105 study evaluated the combination of ociperlimab and tislelizumab, with or without chemotherapy, in patients with metastatic non-small cell lung cancer (NSCLC) and extensive-stage small cell lung cancer…
Renal synovial sarcoma occurring synchronously with renal cell carcinoma.
A patient in his 50s presented with abdominal pain and hematuria, leading to the discovery of a primary biphasic synovial sarcoma of the kidney alongside synchronous clear cell renal cell carcinoma.
18F-FDG PET/CT Manifestations of a Gastrointestinal Stromal Tumor Presenting With Predominant Hepatic and Peritoneal Metastases.
A 70-year-old man presented with abdominal pain. Contrast-enhanced CT demonstrated multiple large space-occupying lesions in the liver.
A phase I, first-in-human dose-escalation and triple-negative breast cancer dose-expansion study of a TROP2-ADC F0024 (FDA018).
This multicenter, first-in-human phase I dose-escalation and dose-expansion study evaluated the TROP2-directed antibody–drug conjugate F0024 (FDA018) in advanced solid tumors, including heavily pretreated…
Venetoclax plus pediatric regimen in adolescents and adults with Ph-negative acute lymphoblastic leukemia.
This phase II multicenter trial evaluated the efficacy of venetoclax combined with pediatric-inspired chemotherapy in 167 adolescents and adults with newly diagnosed Philadelphia chromosome-negative acute lymphoblastic…
First-Line Retlirafusp Alfa Plus Chemotherapy for Human Epidermal Growth Factor Receptor 2-Negative Gastric or Gastroesophageal Junction Adenocarcinoma: A Randomized, Double-Blind, Phase III Study (RELIGHT).
RELIGHT was a randomized, double-blind, phase III trial of first-line retlirafusp alfa plus capecitabine and oxaliplatin (CAPOX) versus placebo plus CAPOX in 731 patients with previously untreated, unresectable, locally…
Association of androgen deprivation therapy and acute kidney injury in patients with prostate cancer: a systematic review and meta-analysis of 72,980 patients.
This systematic review and meta-analysis evaluated the association between androgen deprivation therapy (ADT) and acute kidney injury (AKI) in 72,980 prostate cancer patients.
Kaposiform haemangioendothelioma presentation in hand in a paediatric patient.
A young female patient presented with progressive swelling and discoloration of the pulp of her right middle finger. Initially misdiagnosed as chronic osteomyelitis, further evaluation confirmed the diagnosis of…
Anaphylaxis to both pegfilgrastim and sargramostim in a patient with diffuse large B-cell lymphoma.
A woman in her early 60s with stage 3A diffuse large B-cell lymphoma experienced anaphylaxis to pegfilgrastim after her first cycle of R-CHOP chemotherapy, presenting with syncope and severe hypotension.
Aspirin after curative-intent treatment of colorectal cancer liver metastases (ASAC): a multicentre, phase 3, randomised, double-blind, placebo-controlled trial.
The ASAC phase 3, multicentre, randomised, double-blind, placebo-controlled trial tested aspirin 160 mg daily after curative-intent treatment of colorectal cancer liver metastases.
Effect of Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-Cell activation in postoperative chemotherapy patients with breast cancer .
This randomized controlled trial investigated the effects of a traditional Chinese medicine compound on intestinal bifidobacteria recovery and CD4+ T-cell activation in breast cancer patients undergoing postoperative…
Ivonescimab plus chemotherapy as first-line treatment for advanced thymic carcinoma: preliminary results of a phase II trial with biomarker analyses.
This phase II trial evaluated ivonescimab combined with chemotherapy in seven patients with advanced thymic carcinoma. The study found a promising objective response rate (ORR) of 85.7% and a disease control rate (DCR)…
TACE combined with apatinib versus TACE alone for unresectable hepatocellular carcinoma in China: a cost-effectiveness and budget impact analysis.
This study evaluated the clinical efficacy and cost-effectiveness of transarterial chemoembolisation (TACE) combined with apatinib versus TACE alone for unresectable hepatocellular carcinoma in China.
Effectiveness and Safety of Colorectal Cancer Screening Via Fecal Occult Blood Testing: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the effectiveness of colorectal cancer screening via fecal occult blood tests in adults aged 45-75.
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