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937 articles
July 202624
Prior Decompensation Identifies Patients at High Mortality Risk Despite Standard Therapy After Variceal Hemorrhage: An Individual Patient Data Meta-Analysis.
This systematic review and individual participant data meta-analysis examined whether decompensation before variceal hemorrhage was associated with outcomes in patients with Child-Pugh A-B cirrhosis receiving…
The glucagon and GLP-1 receptor dual agonist DD01 for metabolic dysfunction-associated steatotic liver disease and steatohepatitis (DD01-DN-02): 12-week results from a randomised, double-blind, multicentre, placebo-controlled, phase 2 trial.
The DD01-DN-02 trial, a randomized, double-blind, multicentre, placebo-controlled phase 2 study, evaluated the dual agonist DD01 in adults with metabolic dysfunction-associated steatotic liver disease (MASLD) or…
Polysaccharides-mediated mitochondrial remodeling: role in chemotherapy resistance of gastrointestinal tumors.
This systematic review examined the role of mitochondrial remodeling in chemotherapy resistance in gastrointestinal (GI) tumors and evaluated the potential of polysaccharides as therapeutic agents.
Clinical Trial: Effectiveness and Safety of a Novel Anal Insert Device for Treatment of Faecal Incontinence.
This clinical trial evaluated the safety and effectiveness of the StaySure anal insert device in patients with medically-refractory faecal incontinence (FI).
The Role of Fat-Free Mass in Weight-Related Complications: A Rapid Review and Meta-Analysis.
This meta-analysis reviewed 32 studies involving 138,935 adults with overweight or obesity to assess the relationship between fat-free mass (FFM) metrics and weight-related metabolic complications.
Incidence and risk factors of refeeding syndrome in critically ill patients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the incidence and risk factors of refeeding syndrome (RFS) in critically ill patients, analyzing data from 49 studies with 24,778 participants.
Endoscopic Salvage Following Radiotherapy for Oesophageal Cancer: A Systematic Review.
This systematic review evaluated the safety and efficacy of endoscopic salvage procedures following definitive chemoradiotherapy (dCRT) for locally advanced oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma…
Efficacy and Safety of Endoscopic Treatment for Chronic Hemorrhagic Radiation Enteropathy: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of endoscopic treatments for chronic hemorrhagic radiation enteropathy in 2626 patients.
Beyond gastroenteritis: first evidence of systemic biochemical disturbances, predominantly coagulation dysfunction, in Neoboletus poisoning.
Two incidents of Neoboletus poisoning in Yunnan Province involved eight individuals who consumed wild mushrooms. One patient experienced abdominal pain and dizziness that resolved quickly, while others suffered from…
Sleep and Its Impact on the Success of Weight Loss Interventions in Adults With Excess Weight: A Systematic Review.
This systematic review evaluated the impact of sleep health on weight loss in adults with excess weight undergoing behavioral or surgical interventions. It included 30 studies with 10,944 participants.
Comparative Effects of Four Dietary Approaches on Symptom Severity and Quality of Life in Irritable Bowel Syndrome: A Randomized Controlled Trial.
This randomized controlled trial evaluated the effects of four dietary approaches on symptom severity and quality of life in adults with irritable bowel syndrome (IBS).
Patient-reported outcomes from the TBCRC 022 study of neratinib and ado-trastuzumab emtansine for HER2-positive breast cancer brain metastases.
The TBCRC 022 study, a Phase II multicenter clinical trial, evaluated the gastrointestinal toxicities of neratinib and ado-trastuzumab emtansine in patients with HER2-positive breast cancer brain metastases.
Nuclear Chromatin Heterogeneity in High-Grade PanIN Detected by Serial Pancreatic Juice Aspiration Cytological Examination (SPACE): A Report of Two Cases.
Two cases of high-grade pancreatic intraepithelial neoplasia (high-grade PanIN) were identified through serial pancreatic juice aspiration cytological examination (SPACE).
Oral and Pancreatobiliary Microbiota in Cancer: A Systematic Review of Compositional Alterations and Their Clinical Implications.
This systematic review examined microbial dysbiosis in patients with pancreatobiliary malignancies, analyzing 16 studies with 1426 participants.
A case of portal hypertension associated with a giant hepatic arterioportal fistula successfully treated with partial hepatic arterial embolization.
A woman in her 60s presented with massive ascites and was found on imaging to have a giant intrahepatic arterioportal fistula, with multiple communications between the posterior segmental portal vein and arterial inflow…
Sildenafil-associated severe cholestatic drug-induced liver injury presenting as persistent jaundice after stone extraction.
A 43-year-old man developed abdominal pain and vomiting after regularly taking sildenafil obtained in the Philippines. Imaging showed choledocholithiasis, which was treated successfully by endoscopic stone extraction…
Effects of vitamin D status and supplementation on MASLD severity in individuals with overweight or obesity: a cross-sectional study and randomized controlled trial.
This study examined vitamin D status and MASLD severity in adults with overweight or obesity, combining a cross-sectional analysis with a 24-week randomized controlled trial.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JMKX003002 in Chinese healthy participants: a randomized, double-blind, placebo-controlled, single- and multiple-ascending dose, and food-effect phase I clinical trial.
This phase I randomized, double-blind, placebo-controlled trial assessed the safety, tolerability, pharmacokinetics, and pharmacodynamics of JMKX003002, an NHE3 inhibitor, in healthy Chinese participants.
Gel Immersion Improves Visualization in Underwater Endoscopic Mucosal Resection for Colorectal Lesions: A Prospective Crossover Trial.
This prospective randomized crossover trial evaluated the impact of gel immersion on lesion visibility during underwater endoscopic mucosal resection (UEMR) for colorectal adenomatous lesions.
Liver Transplantation in a Patient With Fulminant Failure and Bone Marrow Aplasia Due to Methimazole: A Case Report.
A 37-year-old man with Graves' disease developed fulminant hepatitis and bone marrow aplasia after four years of methimazole treatment.
Endoscopic Sphincterotomy Plus Large Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Patients with Common Bile Duct Stones: A GRADE Evaluation of Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of endoscopic sphincterotomy with large-balloon dilation (ESBD) versus endoscopic sphincterotomy (ES) alone in adults with common bile duct stones.
Systematic Review: Evaluating the Prognostic Value of Granulomas in Crohn's Disease.
This systematic review evaluated the prognostic value of granulomas in Crohn's disease (CD) by analyzing 46 studies, including 37 cohort analyses.
Optimal dose window, formulation efficacy, and molecular mechanisms of curcumin in MASLD animal models: A systematic review and three-level meta-analysis.
This systematic review and meta-analysis evaluated the efficacy of curcumin in animal models of metabolic dysfunction-associated steatotic liver disease (MASLD).
Peripheral parenteral nutrition improves short-term nutritional status and inflammatory reaction after colorectal resection surgery: A randomized clinical trial.
This randomized controlled trial evaluated the effects of early postoperative peripheral parenteral nutrition (PPN) on nutritional status and inflammatory response in 207 patients after colorectal resection.
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