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464 articles
October 202624
Individual Effects of Angiotensin II Receptor Blockers on Major Adverse Cardiovascular Events: A Systematic Review and Network Meta-Analysis.
This systematic review and random-effects network meta-analysis compared angiotensin II receptor blockers (ARBs) for cardiovascular outcomes in randomized trials not primarily designed to study heart failure.
Wireless Home Blood Pressure Monitoring With Health Coaching for Hypertension Management at a Federally Qualified Health Center: Pilot Randomized Controlled Feasibility and Acceptability Study.
This 6-month, two-arm randomized pilot trial assessed feasibility and acceptability of wireless home blood pressure monitoring (HBPM) with health coaching among adults with uncontrolled or newly diagnosed hypertension…
Effectiveness and safety of atorvastatin/ ezetimibe fixed-dose combination in hypercholesterolemia: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared atorvastatin alone with atorvastatin/ezetimibe free-equivalent and fixed-dose combinations in people with hypercholesterolemia.
AI-Based Clinical Decision Support Systems in Primary Care: Systematic Review of Clinical Implementation.
This systematic review assessed the effectiveness and safety of AI-based clinical decision support systems (AI-CDSSs) used by health professionals in primary care, compared with usual care or non-AI decision support.
Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.
This systematic review of randomized controlled trials assessed supervised, face-to-face non-pharmacological interventions in adults with WHO-defined post-COVID-19 condition.
Chios Mastic in Well-Controlled Hypertension: Findings From the HYPER-MASTIC Randomized Controlled Trial.
This double-blind, randomized, placebo-controlled trial assessed whether Chios mastic provides additional cardiovascular benefits in 106 adults with stable, well-controlled hypertension.
Global Prevalence of Adherence to Antihypertensives and Associated Moderating Factors Among Adults With Hypertension: A Meta-Analysis.
This systematic review and meta-analysis estimated global adherence to antihypertensive medication among adults with hypertension.
Continuous Glucose Monitoring in Non-Insulin-Treated Type 2 Diabetes.
This 26-week, multicenter randomized trial compared continuous glucose monitoring (CGM) with routine care in adults with type 2 diabetes not using insulin at 22 US primary care practices.
Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury.
This multicenter, open-label, randomized noninferiority trial compared intermittent hemodialysis with continuous renal-replacement therapy as initial treatment in critically ill adults with acute kidney injury and…
Life-Threatening Ventricular Tachycardia and Transient Brugada-Like Electrocardiographic Abnormalities Caused by Severe Hyperkalemia Due to Urinary Retention in a 55-Year-Old Man.
A 55-year-old man without known cardiovascular disease presented with palpitations, dyspnea, and diaphoresis, then developed hemodynamically unstable sustained wide-QRS ventricular tachycardia with recurrent episodes…
Early Discharge Strategy Including Subcutaneous Furosemide in Hospitalized Heart Failure.
This multicenter, open-label, randomized active-controlled trial in the United Kingdom studied 172 patients hospitalized with heart failure who still required parenteral diuretics.
Immediate Versus Staged Complete Revascularization in Multivessel Disease and STEMI: A Meta-Analysis of Randomized Trials.
This frequentist meta-analysis of four multicentre randomised trials compared immediate with staged complete revascularization in 2,651 patients with STEMI and multivessel disease.
Postoperative acute kidney injury associated with cast nephropathy and marked renal interstitial plasma cell infiltration in multiple myeloma: a case report.
An 84-year-old man with smoldering multiple myeloma developed severe acute kidney injury after lumbar fixation for a burst fracture.
Blood pressure targets in adults with hypertension.
This publication is a protocol for a Cochrane intervention review, not a report of completed results. It sets out to assess lower blood pressure targets (≤ 135/85 mmHg) versus standard targets (≤ 140 to 160/90 to 100…
Effect of web-based education on NIV-related side effects and insomnia severity in COPD patients using home NIV: a randomized controlled trial.
This randomized controlled trial evaluated web-based education about NIV-related side effects and insomnia management in 75 patients with COPD using home noninvasive ventilation.
Integrated management of atrial fibrillation with digital health support: a pooled analysis of individual participant data from the mAFA-II and MIRACLE-AF trials.
This pooled individual participant data analysis combined two prospective randomised trials of adults with atrial fibrillation: mAFA-II, which delivered ABC pathway care through a mobile app, and MIRACLE-AF, which used…
Disease-Specific Optimal Blood Glucose Control Strategies in Critically Ill Patients: Retrospective Cohort Study and Network Meta-analysis.
This study combined a retrospective MIMIC-IV cohort analysis with a frequentist network meta-analysis of randomized trials to examine glucose-control targets in critically ill patients with sepsis, cardiac disease, or…
Lamotrigine-associated SJS/TEN overlap during valproate co-therapy managed with rhTNFR-Fc and therapeutic plasma exchange: A case report.
A 49-year-old man receiving valproate developed fever and a rapidly spreading erythematous maculopapular eruption after lamotrigine was started at 50 mg once daily.
Kartagener syndrome with pulmonary mycetoma and recurrent thromboembolism: A case report.
A 27-year-old man with Kartagener syndrome and situs inversus totalis presented with worsening dyspnea, chest pain, fever, hemoptysis, and ankle swelling, against a history of deep vein thrombosis, recurrent pulmonary…
Increased mean corpuscular hemoglobin concentration: A case report as an early clue of chronic severe hyponatremia.
An 81-year-old woman was admitted after three days of altered mental status. Her complete blood count showed a markedly elevated mean corpuscular hemoglobin concentration (MCHC) of 369 g/L; the blood smear showed…
Self-care practices of people living with HIV and hypertension or diabetes comorbidities in low-and-middle income countries: A systematic review.
This systematic review synthesised qualitative research on self-care among people living with HIV and hypertension or diabetes in low- and middle-income countries.
Blinded withdrawal of randomized treatment with low-dose digoxin or placebo in heart failure: the DECISION trial.
This pre-specified analysis of the multicentre, randomised DECISION trial examined blinded withdrawal of long-term low-dose digoxin or placebo in patients with heart failure and reduced or mildly reduced ejection…
Etrasimod reduces circulating and mucosal inflammatory lymphocyte populations and alters innate immune and non-immune cell signatures in intestinal mucosa: ELEVATE UC phase 3 clinical data.
This analysis of the phase 3 ELEVATE UC randomised trials characterised blood and intestinal mucosal changes in patients with ulcerative colitis treated with etrasimod or placebo.
Real-World Effectiveness of AI-Enabled Clinical Decision Support in Primary Care: Systematic Review.
This systematic review synthesized real-world evaluations of clinician-facing AI-enabled clinical decision support in primary and ambulatory care, covering studies published from 2011 through 2025.
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