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937 articles
August 202624
Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial.
The STAR-TREC trial evaluated long-course chemoradiotherapy (LCCRT) versus short-course radiotherapy (SCRT) for organ preservation in early-stage and intermediate-stage rectal cancer.
Optimization of Minocycline-Containing Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Randomized Controlled Trial.
This randomized controlled trial evaluated the efficacy and safety of minocycline-containing bismuth quadruple therapy for Helicobacter pylori rescue treatment in 480 refractory patients.
Older adults with resectable gastric cancer undergoing perioperative chemotherapy or preoperative chemoradiotherapy plus perioperative chemotherapy: A secondary analysis of the AGITG TOPGEAR phase III trial.
This secondary analysis of the AGITG TOPGEAR phase III trial evaluated older adults (≥70 years) with resectable gastric cancer undergoing perioperative chemotherapy or chemoradiotherapy.
Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases.
This systematic review evaluated the pharmacokinetics of IL-23p19 inhibitors across various immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD).
[Translated article] Evidence on the impact of treatment optimization on the safety of patients with liver cirrhosis.
This systematic review assessed whether optimizing medication therapy improves medication-related safety in people with liver cirrhosis.
Risk prediction models for hepatic encephalopathy post-transjugular intrahepatic portosystemic shunt: A systematic review and critical appraisal.
This systematic review assessed prediction models for hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS), including studies with at least 100 patients.
Self-Directed Mikoto Simulator Training for Colonoscopy in Gastroenterology Trainees: An International Multicenter Randomized Trial.
This multicenter randomized trial evaluated the impact of self-directed mikoto simulator training on colonoscopy insertion performance among 12 gastroenterology trainees across Japan and Taiwan.
Atezolizumab with or without tiragolumab in unresectable esophageal squamous-cell carcinoma following definitive concurrent chemoradiotherapy (SKYSCRAPER-07): a randomised, phase III study.
SKYSCRAPER-07 was a global, randomised, placebo-controlled phase III trial of 760 adults with unresectable esophageal squamous-cell carcinoma after definitive concurrent chemoradiotherapy.
Long-term microbiome and clinical effects of a microbiome-guided personalized diet versus low-FODMAP diet in irritable bowel syndrome: A 12-month follow-up randomized controlled trial.
This multicenter randomized controlled trial evaluated the long-term effects of a microbiome-guided personalized diet (PD) versus a low-FODMAP diet (LFD) in adults with irritable bowel syndrome (IBS).
Effects of diabetes, obesity, and metabolic syndrome on alcohol-associated liver disease: A systematic review.
This systematic review evaluated the impact of cardiometabolic risk factors (CMRFs) on clinical outcomes in adults with alcohol-associated liver disease (ALD).
Hepatotoxicity of OBS: A review of the emerging PFOS substitute.
This systematic review evaluates the hepatotoxic effects of sodium perfluorononenyl oxobenzene sulfonate (OBS), an alternative to PFOS, across various studies.
Efficacy, Safety, and Pharmacokinetics of Upadacitinib Among Patients in East Asia With Moderately to Severely Active Ulcerative Colitis: A Post Hoc Subanalysis of Randomized Phase 3 Studies.
This post hoc subanalysis of Phase 3 randomized trials evaluated the efficacy, safety, and pharmacokinetics of upadacitinib in East Asian patients with moderately to severely active ulcerative colitis.
Food intake sequence affects postprandial metabolic, hormonal, and appetite responses in healthy male football players: A randomised crossover trial.
This randomized crossover trial examined the effects of food intake sequence on postprandial responses in 14 highly trained male football players.
Influence of artificial intelligence on the performance of endosonographers in detection of solid pancreatic tumors: a tandem randomized video study.
This randomized controlled trial evaluated the impact of an AI-based software system on endosonographers' performance in detecting solid pancreatic tumors (SPTs) using curated EUS videos.
Evaluating surgical management of primary achalasia-a systematic review and network meta-analysis of randomized clinical trials.
This systematic review and network meta-analysis evaluated the outcomes of various surgical interventions for primary achalasia in 1170 patients across 15 randomized clinical trials.
Delayed Esophageal Perforation With Esophagomediastinal Fistula and Mediastinal Abscess Mimicking Malignancy on 18 F-FDG PET/CT After Hard Fish Chunk Impaction.
A 74-year-old woman with a pulmonary nodule showing interval growth on follow-up imaging presented with dysphagia and abdominal bloating.
Multimodal management of refractory gastrointestinal bleeding in myeloma-associated acquired von Willebrand syndrome: a role for emicizumab prophylaxis.
A 72-year-old woman with IgG κ multiple myeloma, acquired von Willebrand syndrome, and gastrointestinal angiodysplasia had recurrent life-threatening bleeding despite factor concentrates, intravenous immunoglobulin…
Cutibacterium avidum caused a liver abscess after transarterial chemoembolization for hepatocellular carcinoma.
An 83-year-old man developed a liver abscess following transarterial chemoembolization for recurrent hepatocellular carcinoma, presenting with fever 10 days post-procedure.
Hemostatic Efficacy and Safety of the Hybrid Injector ClearCoajet in Endoscopic Mucosal Resection of Large Colorectal Polyps: A Multicenter Randomized Trial.
This multicenter randomized trial evaluated the hemostatic efficacy and safety of the ClearCoajet device during endoscopic mucosal resection of large colorectal polyps in 220 patients.
Consolidation Therapy of Probiotics With Rifaximin Prevent Relapse in Rifaximin-Responsive Diarrhea-Predominant Irritable Bowel Syndrome: A Multicenter Randomized Clinical Trial.
This multicenter randomized clinical trial evaluated the effectiveness of consolidation therapy with Medilac-S probiotics following rifaximin treatment in patients with diarrhea-predominant irritable bowel syndrome…
Under pressure: A phase I pilot trial evaluating pressurised intraperitoneal aerosol chemotherapy with oxaliplatin in resectable high-risk gastric cancer.
This prospective, single-centre, non-randomised, open-label phase I pilot trial assessed the safety and feasibility of adding pressurised intraperitoneal aerosol chemotherapy with oxaliplatin (PIPAC-O+) to perioperative…
Efficacy of Luseogliflozin Added to Semaglutide in Patients With Metabolic Dysfunction-Associated Steatohepatitis and Type 2 Diabetes Mellitus: A Randomised, Open-Label Trial.
This 52-week, open-label, randomised, parallel-group trial in Japan compared luseogliflozin plus semaglutide with semaglutide alone in adults with biopsy-proven MASH and type 2 diabetes.
Effectiveness of multitarget stool DNA versus faecal immunochemical testing alone in detecting colorectal cancer and advanced polyps: A systematic review.
This systematic review evaluated the effectiveness of multitarget stool DNA (mt-sDNA) compared to faecal immunochemical testing (FIT) for detecting colorectal cancer (CRC) and advanced polyps.
Defining Clinically Significant Radiographic Recurrence after Paraesophageal Hernia Repair: Post Hoc Analysis of Patient-Reported Outcomes and Reoperation from a Randomized Controlled Trial.
This post hoc analysis of a randomized controlled trial evaluated the correlation between radiographic recurrence size and reoperation rates as well as patient-reported outcomes in adults undergoing minimally invasive…
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