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937 articles
August 202624
An Oxycodone-Based Conscious Analgesia Strategy with Supplemental Low-Dose Propofol Improves Safety in Elderly Obese Patients Undergoing Gastroscopy: A Prospective Randomized Controlled Trial.
During diagnostic gastroscopy, intolerance is usually manifested as retching, coughing, and involuntary movement. Conscious analgesia relieves discomfort while patients continue to breathe spontaneously and remain…
Subcentimeter Ileal Neuroendocrine Tumor Resection for Obscure Gastrointestinal Bleeding Followed by Pacemaker-Treated Sick Sinus Syndrome: A Case Report.
A 72-year-old man presented with melena and abdominal discomfort, with prior endoscopies yielding no diagnosis. Multiphase computed tomographic enterography identified an 11×8 mm enhancing nodule in the distal small…
Liver transplant allocation by milan criteria may exclude eligible HCC patients without survival benefit - a post-hoc analysis of the SiLVER study.
This post-hoc analysis of the SiLVER Study evaluated the Milan criteria for liver transplant eligibility in 485 patients with hepatocellular carcinoma (HCC).
A 12-week home-based exercise program with nutritional guidance is associated with improved functional capacity in chronic liver disease.
This prospective clinical trial evaluated a 12-week home-based exercise program with nutritional guidance in 46 patients with chronic liver disease (CLD).
Long-term outcome after fetal endoscopic tracheal occlusion for congenital diaphragmatic hernia: systematic review.
This systematic review assessed long-term outcomes after fetal endoscopic tracheal occlusion (FETO) for congenital diaphragmatic hernia (CDH).
Atezolizumab-bevacizumab with or without cisplatin-based HAIC for unresectable HCC: A randomized phase II trial.
This multicenter, open-label, randomized phase II trial compared sequential cisplatin hepatic arterial infusion chemotherapy (HAIC) followed by atezolizumab-bevacizumab with atezolizumab-bevacizumab alone in patients…
Long-Term Restoration of Anticoagulant Function After Liver Transplantation for Severe Congenital Protein C Deficiency: A Single-Center Experience Involving Three Pediatric Patients.
Three pediatric patients with severe congenital protein C deficiency underwent liver transplantation, resulting in plasma protein C activity levels exceeding 64% post-surgery.
Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm.
A 48-year-old woman presented with an incidental pancreatic head mass. Cytological analysis from endoscopic ultrasound-guided fine-needle aspiration revealed tumor cells with eccentric nuclei and prominent eosinophilic…
Effect of diet macronutrient content on the cardiometabolic response to weight loss: A randomized clinical trial.
This randomized clinical trial examined the impact of different macronutrient compositions in diets on cardiometabolic responses to moderate weight loss in individuals with metabolically unhealthy obesity.
Repeated normothermic intraperitoneal paclitaxel perfusion via videolaparoscopy (RIPPENC-VLP) combined with CAPOX for gastric cancer with positive cytology or limited peritoneal metastasis: A prospective phase II study.
This prospective, single-centre phase II study evaluated repeated normothermic intraperitoneal paclitaxel perfusion via videolaparoscopy plus systemic CAPOX in patients with gastric adenocarcinoma and positive…
Clinical Trial: Intensive Supervised Nutritional Therapy Versus Guideline-Based Nutritional Advice for Sarcopenia in Decompensated Cirrhosis-A Randomised Controlled Trial.
This randomized controlled trial evaluated the effectiveness of dietitian-supervised intensive nutritional therapy versus physician-led guideline-based dietary advice in 180 patients with decompensated cirrhosis and…
ALG-055009 in non-cirrhotic adults with metabolic dysfunction-associated steatohepatitis (HERALD): a randomised, double-blind, placebo-controlled, phase 2a trial.
The HERALD study was a randomised, double-blind, placebo-controlled phase 2a trial of once-daily ALG-055009 in non-cirrhotic adults with presumed MASH and F1–F3 fibrosis.
Distinguishing focal nodular hyperplasia from hepatocellular adenoma on contrast-enhanced ultrasound: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed contrast-enhanced ultrasound (CEUS) for distinguishing focal nodular hyperplasia (FNH) from hepatocellular adenoma (HCA), using histopathology or MRI with hepatobiliary…
A systematic review of Mendelian randomization evidence on alcohol-related phenotypes and multiple human diseases.
This systematic review synthesised Mendelian randomization studies using genetic variants as instruments for alcohol consumption, alcohol use disorder, or related measures to assess associations with health outcomes.
Gut microbial diversity at baseline conditions the clinical, microbiome, and metabolic response to paraprobiotic Lactiplantibacillus plantarum LRCC5282 in overweight adults.
This randomized controlled trial investigated the impact of baseline gut microbial diversity on the response to the paraprobiotic Lactiplantibacillus plantarum LRCC5282 in 120 overweight adults over 12 weeks.
Efficacy of dapagliflozin on hepatic steatosis and fibrosis in patients with type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease: a pre-specified single-arm analysis from a randomized controlled trial.
This study evaluated the effects of dapagliflozin on hepatic steatosis and fibrosis in patients with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD) over 12 months.
Lactose and sucrose each stimulate hepatic de novo lipogenesis: A randomized crossover trial.
This randomized crossover trial evaluated the effects of lactose on hepatic de novo lipogenesis (DNL) in 24 adults without obesity.
On-demand transarterial chemoembolisation combined with atezolizumab and bevacizumab in patients with untreated hepatocellular carcinoma (TALENTACE): a multicentre, randomised, open-label, phase 3 trial.
TALENTACE was a multicentre, open-label, randomised phase 3 trial comparing on-demand transarterial chemoembolisation (TACE) plus atezolizumab and bevacizumab with TACE alone in 342 patients with untreated, unresectable…
Cardiorespiratory and Metabolic Responses After Sleeve Gastrectomy in Adults With Obesity: Systematic Review.
This systematic review examined cardiorespiratory and metabolic responses after sleeve gastrectomy in adults with obesity. It included seven observational reports involving 162 participants from two independent cohorts…
Peripheral and splanchnic venous thromboembolism in acute and infected necrotizing pancreatitis: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis pooled venous thromboembolism incidence after acute necrotizing pancreatitis, including an infected-necrosis subgroup.
Gut Health and Integrative Primary Care.
The article describes a patient with gastrointestinal symptoms considered from an integrative primary-care perspective. The abstract does not specify the patient’s presentation, evaluation findings, diagnosis…
Meta-Analysis: Enhanced Liver Fibrosis (ELF) Test for Identifying Significant Fibrosis, Advanced Fibrosis, and Cirrhosis in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.
This meta-analysis evaluated the Enhanced Liver Fibrosis (ELF) test for identifying significant fibrosis (≥F2), advanced fibrosis (≥F3), and cirrhosis (F4) in patients with metabolic dysfunction-associated steatotic…
Yukgunja-tang and Pyeongwi-san improve functional dyspepsia and modulate ghrelin dynamics: A multicenter randomized controlled trial.
This multicenter, assessor-blind randomized controlled trial compared Yukgunja-tang (YGJ) and Pyeongwi-san (PWS) with usual care (UC) in 140 patients with functional dyspepsia treated for 6 weeks.
Single-stage surgical management versus conventional two-stage management for pediatric choledocholithiasis: A systematic review and meta-analysis.
This systematic review and random-effects meta-analysis compared single-stage with conventional two-stage management of choledocholithiasis in children. Eight retrospective cohort studies included 562 patients.
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