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2000 articles
October 202624
Case report: successful use of repotrectinib in a ROS1 fusion-positive lung adenocarcinoma patient with severe renal insufficiency and prior tyrosine kinase inhibitor treatment failure.
A 69-year-old woman with advanced lung adenocarcinoma harboring an SDC4–ROS1 fusion had bilateral pulmonary lesions, mediastinal lymphadenopathy, and pleural effusions.
Fractal radiomics as a virtual biopsy in glioma: A systematic review and meta-analysis of molecular status, radiogenomic associations, and survival outcomes.
This systematic review and meta-analysis assessed whether fractal-based imaging features can predict molecular alterations and outcomes in glioma.
Sunitinib in Patients With Various Solid Tumors With FGFR1 / 2 Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.
This phase II basket trial evaluated sunitinib in patients with advanced solid tumours and FGFR1 or FGFR2 alterations who had no remaining standard treatment options. Histology-specific cohorts were pooled by alteration.
Neoadjuvant niraparib monotherapy for unresectable, homologous recombination deficiency-positive, high-grade serous ovarian cancer (NANT): a multicentre, single-arm, phase 2 trial.
This multicentre, single-arm phase 2 trial evaluated two cycles of neoadjuvant niraparib monotherapy in treatment-naïve patients with HRD-positive, advanced high-grade serous or endometrioid ovarian cancer considered…
Effectiveness of psychosocial interventions addressing informal caregivers' mental health: an umbrella systematic review with 26,481 participants.
This umbrella systematic review and random-effects meta-analysis assessed psychosocial interventions for the mental health of informal caregivers, grouped by care recipients’ clinical conditions.
Immune-related colitis following head and neck reconstructive surgery in a patient receiving long-term nivolumab.
A man with gastric cancer, receiving long-term nivolumab and prednisolone for immune-related myositis, underwent subtotal glossectomy for advanced tongue cancer. On postoperative day 4, he developed grade 3 diarrhoea.
MK-4002, a B-cell maturation antigen-targeting T-cell engager, in relapsed or refractory multiple myeloma: a first-in-human, open-label, phase 1 study.
This first-in-human, open-label, multicentre phase 1 study evaluated the safety, pharmacokinetics, and preliminary activity of the BCMA-targeting T-cell engager MK-4002 in adults with heavily pretreated relapsed or…
Genome-wide meta-analysis dissects the genetic basis and health implications of circulating taurine.
This genome-wide meta-analysis examined the genetic basis of circulating taurine levels in 36,490 European individuals. The study identified six common and two rare genetic loci associated with taurine levels and…
5-year survival rate and determinants of decreased survival among patients with breast cancer in Africa: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the 5-year survival rate of breast cancer patients in Africa, analyzing 55 studies with 19,577 participants. The pooled 5-year survival rate was found to be 40.38%.
Adamantinoma-like Ewing sarcoma of the bladder.
A patient presented with a bladder tumor initially diagnosed as urothelial carcinoma following transurethral resection. After receiving neoadjuvant chemotherapy with methotrexate, vinblastine, doxorubicin, and…
Efficacy and safety of MEK inhibitors for NF1-associated symptomatic, inoperable plexiform neurofibromas: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of MEK inhibitors for treating symptomatic, inoperable plexiform neurofibromas in patients with neurofibromatosis type 1 (NF1).
Febrile neutropenia in adults with diffuse large B-cell lymphoma receiving first-line R-CHOP-based therapy: a systematic review and meta-analysis of observational and trial evidence.
This systematic review and meta-analysis assessed febrile neutropenia (FN) in adults with diffuse large B-cell lymphoma receiving first-line R-CHOP or R-CHOP-like therapy, separating observational cohorts from clinical…
Infection burden in mismatched unrelated donor hematopoietic cell transplantation: results from the ACCESS trial.
The ACCESS trial evaluated infection burden in 268 adult patients undergoing HLA-mismatched unrelated donor hematopoietic cell transplantation (HCT) with posttransplant cyclophosphamide (PTCy) for graft-versus-host…
Same-day diagnosis and robotic resection of rare primary pulmonary melanoma: a robotic bronchoscopy-guided approach.
A man in his 70s presented with a lingular pulmonary nodule suspicious for non-small cell lung cancer. He underwent robotic navigation bronchoscopy for biopsy, which was followed by robotic-assisted thoracic surgery.
Metabolic Bariatric Surgery for Cancer Prevention and Risk Reduction in Patients with Obesity: A GRADE-Based International Federation for the Surgery and Other Therapies for Obesity (IFSO) Position Statement.
This GRADE-based international position statement systematically reviewed evidence on metabolic bariatric surgery (MBS) and cancer incidence in adults with obesity, comparing surgery with non-surgical weight-loss…
World's first case report of live birth following autologous ovarian tissue cryopreservation and transplantation in a patient with colon carcinoma.
A 29-year-old woman with colon cancer underwent ovarian tissue cryopreservation prior to chemotherapy. After developing premature ovarian insufficiency, she received two transplantations of thawed ovarian cortex strips.
Fatal drug-induced liver injury in the setting of abemaciclib therapy for metastatic breast cancer.
A Hispanic woman in her mid-60s with metastatic ER+/HER2- breast cancer developed severe mixed hepatocellular-cholestatic injury one month after starting abemaciclib with letrozole.
Adrenal metastasis from papillary thyroid cancer: staged surgical resection.
A man in his 70s with a history of papillary thyroid carcinoma presented with recurrence in the right cervical lymph nodes and a right adrenal mass measuring 5.7×6.5 cm. A CT-guided biopsy confirmed metastatic disease.
A study on the intervention effect of a structured grief counseling program on grief responses in family caregivers of patients with advanced cancer.
This randomized controlled trial evaluated the impact of structured grief counseling on grief responses in family caregivers of advanced cancer patients.
Restorative resection in robot-assisted versus laparoscopic total mesorectal excision: systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the outcomes of robot-assisted total mesorectal excision (R-TME) versus laparoscopic total mesorectal excision (L-TME) in rectal cancer surgery, involving 7133 patients…
Reduced venesection requirement as a clue to occult colorectal cancer in hereditary haemochromatosis.
A man in his late 70s with hereditary haemochromatosis experienced an unexpected cessation of his usual venesection for iron management, despite no gastrointestinal symptoms or anemia.
Impact of opioid-free general anesthesia with locoregional blocks during breast cancer surgery on systemic inflammatory response: results from a randomized controlled trial.
This randomized controlled trial evaluated the effects of opioid-free general anesthesia with locoregional blocks (OfGA) versus traditional opioid-based general anesthesia (GA) on postoperative inflammation in breast…
Preoperative CA15-3 as a predictor of axillary lymph node metastasis and prognosis in women with breast cancer: a GRADE-assessed systematic review and meta-analysis.
This GRADE-assessed systematic review and random-effects meta-analysis examined cohort studies of preoperative CA15-3 in women with breast cancer, assessing survival and metastatic outcomes.
Left Atrial Appendage Occlusion Among Cancer Patients With Atrial Fibrillation: A Systematic Review and Updated Meta-Analysis.
This systematic review and updated meta-analysis assessed long-term outcomes after left atrial appendage occlusion (LAAO) in patients with atrial fibrillation and cancer.
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