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1357 articles
November 202624
Caring Contacts and Suicidality Among American Indian and Alaska Native Communities: A Randomized Clinical Trial.
The CARE study was a blinded, two-group randomized clinical trial of 709 American Indian and Alaska Native adults with active suicidality across five communities.
Treatment of Small Peri-Implant Buccal Dehiscence Defects With SCTG or GBR: 3-Year Results of a Pilot Study.
This pilot randomized controlled trial compared subepithelial connective tissue grafting (SCTG) with guided bone regeneration (GBR) for small (≤ 3 mm) buccal bone dehiscences after single implant placement.
Neoadjuvant PD-L1/TGF-β blockade can rapidly disrupt the tumor stroma in head and neck cancer patients.
This window-of-opportunity clinical study examined neoadjuvant bintrafusp alfa, a dual PD-L1 and TGF-β inhibitor, in patients with head and neck squamous cell carcinoma.
Proteomic and Metabolomic Profiling in Moyamoya Disease: A Systematic Review.
This systematic review examined human studies using high-throughput proteomic or metabolomic methods on serum or cerebrospinal fluid in Moyamoya disease (MMD). Of 3,071 records identified, 31 studies were included.
Sunlight Exposure and Breast Cancer Risk: A Systematic Review and Meta-analysis.
This systematic review and random-effects meta-analysis combined 31 epidemiologic studies to assess sunlight exposure and breast cancer incidence, subtype, and survival.
Effect of topical insulin in diabetic foot ulcer healing among patients with diabetes in Asia: a systematic review.
This systematic review assessed topical insulin for diabetic foot ulcer healing in patients with diabetes in Asian countries.
The Effect of Perioperative Video Interventions on Postoperative Pain Control: A Systematic Review.
This systematic review examined randomized controlled trials of perioperative video interventions in adult surgical patients, assessing postoperative pain intensity and analgesic consumption.
Microbiota-derived urolithins and cortical thickness in cognitively healthy older adults: a longitudinal MRI analysis of the WAHA trial.
This longitudinal MRI sub-study within the randomized WAHA trial examined whether changes in urinary microbiota-derived urolithins tracked with cortical-thickness changes in cognitively healthy older adults.
Cost-Effectiveness of Remote Symptom Monitoring During Adjuvant Endocrine Therapy in Breast Cancer.
This economic evaluation used data from a randomized trial of adult women initiating adjuvant endocrine therapy for early-stage breast cancer, comparing remote symptom monitoring via an app, an app with tailored…
Prognostic value of the systemic inflammation response index (SIRI) in glioma: A meta-analysis.
This meta-analysis assessed whether the systemic inflammation response index (SIRI) predicts outcomes in patients with glioma. It pooled evidence from eight retrospective cohort studies involving 1,778 patients.
European Guidelines on Multidisciplinary Management of Obstructed Defecation Syndrome-ESCP, UEG, ESGAR, EAGEN, ESGENA, ESNM and ESPCG.
These European multidisciplinary practice guidelines address diagnosis and management of obstructed defecation syndrome (ODS).
ChatGPT and Other Large Language Models in Inflammatory Arthritis: A Systematic Review Across Clinical Tasks.
This systematic review assessed large language model performance across clinical tasks in inflammatory arthritis. It included 18 studies spanning rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, gout…
Pilot Implementation of an Adapted Online Clinic-Community Model for Childhood Obesity.
This two-arm randomized controlled trial assessed feasibility, acceptability, and preliminary effectiveness of an adapted online family-based clinic-community intervention for children aged 4 to < 8 years with…
Effect of Exercise Interventions on Sarcopenia-Related Outcomes in Older Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed structured exercise versus nonexercise control in adults with type 2 diabetes whose mean age was at least 65 years.
The shared genetic architecture of the TDP-43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes.
This inverse-variance fixed-effects and random-effects meta-analysis examined shared genetic associations across neuropathological TDP-43 conditions and clinically diagnosed frontotemporal lobar degeneration (FTLD).
Genotypic-Phenotypic Correlations in Non-HbE β-Thalassemia Intermedia: A Geographic Systematic Review.
This PRISMA-guided systematic review qualitatively synthesized 21 studies of genotype–phenotype correlations in non-HbE β-thalassemia intermedia, a heterogeneous disorder now included within non-transfusion-dependent…
Natriuretic Peptides as Adjunctive Biomarkers for the Detection of Paroxysmal Atrial Fibrillation in Patients With Cryptogenic Stroke: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed natriuretic peptides as adjunctive tests for detecting paroxysmal atrial fibrillation (PAF) in adults with cryptogenic stroke.
Transcranial Pulse Stimulation in Parkinson's Disease: A Systematic Review.
This systematic review assessed clinical, neurophysiological, imaging, and safety outcomes of transcranial pulse stimulation (TPS) in adults with idiopathic Parkinson’s disease.
Clindamycin and bacterial load reduction as prophylaxis for surgical site infection after below-knee flap and graft procedures.
This randomised controlled trial evaluated clindamycin prophylaxis and preoperative chlorhexidine washing in consecutive patients undergoing below-knee flap or graft procedures.
Do People With Tophaceous Gout Require More Allopurinol for Good Clinical Outcomes? Analysis of 2 Randomized Controlled Trials of Allopurinol Dose Escalation.
This analysis of individual participant data from two randomized allopurinol dose-escalation trials compared outcomes in people with gout with and without baseline tophi.
Phase 1 Evaluation of the Pharmacokinetics of Sevasemten (EDG-5506) for Potential Food Effect and Drug-Drug Interaction With a CYP3A4 Moderate Inhibitor.
This Phase 1, open-label, parallel study assessed the pharmacokinetics of sevasemten in healthy subjects across three cohorts: sevasemten alone while fasted, with verapamil, and after a high-fat meal.
Sleep Management and Recovery After TBI in Kids (SMART-Kids): Pilot Trial Using Melatonin.
This pilot randomized, double-blinded, placebo-controlled trial assessed early melatonin plus sleep education in children aged over 6 to 18 years hospitalized after traumatic brain injury (TBI).
Effects of Multicomponent Training on Body Composition and Cardiorespiratory Fitness in Adults With Type 2 Diabetes: A Randomized Controlled Trial.
This randomized controlled trial assessed 14 weeks of small-sided soccer training in adults aged 40–70 years with type 2 diabetes.
Therapeutic Horseback Riding for Youth With Autism and Psychiatric Comorbidities: A Randomized Trial.
This multisite randomized controlled trial evaluated equine-assisted activities in youth aged 6–16 years with autism and psychiatric comorbidity.
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