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1357 articles
November 202624
Primary Endocrine Therapy vs Upfront Surgery for Older Women With Estrogen Receptor-Positive Breast Cancer: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared primary endocrine therapy (pET) with upfront surgery for operable, nonmetastatic, estrogen receptor-positive breast cancer in older women.
Generative Artificial Intelligence and Maternal Health Outcomes in Pregnant and Postpartum Individuals: A Randomized Clinical Trial.
This 2-group randomized clinical trial assessed whether a generative AI maternal health chatbot improved outcomes among 400 pregnant or postpartum participants from racial and ethnic minoritized groups recruited across…
A Comparative Study of the Efficacy and Safety of Two Misoprostol Regimens for Labour Induction at Term in Delta State: A Two-centre Triple-blind Randomised Controlled Trial.
This two-centre, triple-blind randomised controlled trial compared hourly titrated oral misoprostol with four-hourly 25 mcg vaginal misoprostol for labour induction in 260 singleton term pregnancies in Delta State…
Safety, Biodistribution, and Dosimetry of FAP and Integrin α v β 3 Dual-Targeting Radioligand 177 Lu-DOTA-FAPI-RGD: Preclinical Validation and First-in-Human Study in Patients with Advanced Adenocarcinomas.
This phase I, first-in-human study evaluated the safety, biodistribution, dosimetry, and preliminary efficacy of the dual-targeting radioligand 177Lu-LNC1009 in nine patients with advanced solid tumors and positive…
Comparison of Traumatic Complications following Prostate Biopsy in Men with Lower Urinary Tract Symptoms Due to Prostate Disease Using Biopty Gun versus Semiautomatic Needle.
This randomised comparative study assessed pain and bleeding after digitally guided transrectal prostate biopsy using a semiautomatic needle or a fully automatic biopty gun in 64 men with lower urinary tract symptoms…
Safety and Efficacy of Intratumoral MEDI1191, an IL12 mRNA Lipid Nanoparticle, plus Intravenous Durvalumab in Patients with Advanced Solid Tumors: A First-in-Human Study.
This open-label, multicenter, first-in-human phase I dose-escalation study evaluated intratumoral MEDI1191, an IL-12 mRNA lipid nanoparticle, with intravenous durvalumab in adults with advanced or metastatic solid…
Low-level laser therapy in ulcerative lesions in leprosy: a systematic review.
This systematic review assessed whether low-level laser therapy (LLLT) improves healing of ulcerative lesions in people with leprosy.
RELAX Perinatal Digital Intervention to Prevent Increasing Anxiety: A Randomized Clinical Trial.
This multisite, phase 2b randomized clinical trial tested whether a self-led, pregnancy-tailored digital cognitive bias modification intervention added to usual maternity care could prevent rising anxiety in pregnant…
A Scalable Teacher Professional Development and Wellness Program in Primary Schools: A Cluster Randomized Clinical Trial.
This cluster randomized clinical trial evaluated professional development (PD), with or without a teacher-wellness enhancement (PDT), in 47 urban and rural primary schools in Uganda.
Dual Inhibition of LAG-3 and PD-1 with IBI110 and Sintilimab in Advanced Alveolar Soft Part Sarcoma: A Single-Center, Phase II Trial.
This open-label, single-center phase II trial evaluated IBI110 plus sintilimab in 28 patients with advanced alveolar soft part sarcoma (ASPS), including patients who were naïve or resistant to prior immune checkpoint…
A Phase I First-Time-in-Human, Open-label Study of Nelistotug Administered to Patients with Advanced Solid Tumors.
This first-in-human, open-label, nonrandomized, multicenter phase I study evaluated nelistotug, an anti-CD96 antibody, alone or with dostarlimab, and in a three-drug combination with dostarlimab and belrestotug in…
Pharmacological treatment of bereavement-related distress: a systematic review.
This systematic review assessed pharmacological treatments for bereavement-related psychological distress, including depression following bereavement.
Danvatirsen plus Pembrolizumab versus Pembrolizumab for Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma (PEMDA-HN): A Randomized, Phase II Trial.
PEMDA-HN was a multicenter, open-label, randomized phase II trial comparing first-line danvatirsen plus pembrolizumab with pembrolizumab alone in patients with previously untreated, PD-L1-positive recurrent or…
Acceptability of a patient support and educational intervention for black breast cancer survivors.
This clinical trial evaluated the feasibility and acceptability of a six-week group support and education intervention for English-speaking Black women who had survived stage I–III breast cancer diagnosed within the…
Optimizing the Therapeutic Index: Sequential Intraarterial-Intravenous PRRT with Personalized Volumetric-Adjusted Dosing.
This prospective clinical trial assessed a personalized sequence of intraarterial then intravenous 177Lu-DOTATATE in 10 adults with progressive, nonresectable, liver-dominant metastatic gastroenteropancreatic…
Leptomeningeal carcinomatosis arising from esophageal cancer: a systematic review of the literature.
This systematic review synthesized 31 studies describing 43 patients with leptomeningeal carcinomatosis arising from esophageal cancer.
Associations of Health Literacy and eHealth Literacy With Patient Portal Access and Use: Systematic Review.
This systematic review synthesized quantitative studies of health literacy and eHealth literacy in relation to real-world patient portal access and use among adults.
Neoadjuvant Nivolumab plus Carboplatin and Paclitaxel in Patients with Locally Advanced Resectable Squamous Cell Carcinoma of the Head and Neck: A Phase II, Single-Arm Trial.
This single-arm, open-label phase II trial evaluated neoadjuvant nivolumab plus carboplatin and paclitaxel in patients with newly diagnosed, locally advanced, resectable head and neck squamous cell carcinoma, including…
Fucoidan as an anti-inflammatory and immunomodulatory agent in humans: a systematic review of clinical evidence and translational potential.
This systematic review assessed human interventional studies of fucoidan supplementation for inflammatory, immune, metabolic, and tumour-related outcomes.
The risk of rhegmatogenous retinal detachment associated with topical pilocarpine: a systematic review.
This systematic review assessed whether topical pilocarpine is associated with rhegmatogenous retinal detachment (RRD) in patients aged 40 years or older, synthesising 10 comparative studies.
Drug-drug interactions between statins and antibiotics: A systematic review and meta-analysis of observational studies.
This systematic review and meta-analysis assessed observational evidence on muscle toxicity when statins are used with interacting antibiotics, compared with statin therapy alone.
Germline Genetic Variants and Epilepsy Surgery Response: Individual Participant Pooled Analysis of 272 Patients.
This systematic review and individual-participant pooled analysis examined seizure outcomes after resection or laser ablation in 272 people with pathogenic or likely pathogenic germline epilepsy variants, excluding…
Full-Service Mobile Food Markets and Dietary Quality in Low-Income Housing Communities: A Randomized Clinical Trial.
This cluster randomized clinical trial evaluated weekly full-service mobile market service at 12 subsidized housing sites in the Minneapolis–St. Paul area.
A Phase II Trial of Pembrolizumab plus Granulocyte-Macrophage Colony-Stimulating Factor in Advanced Biliary Cancer.
This single-center phase II trial evaluated pembrolizumab plus GM-CSF in 42 patients with advanced biliary cancers previously treated with chemotherapy and without prior immune checkpoint inhibitor therapy.
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