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1357 articles
November 202624
Co-Designed Text Messaging Intervention for Parents of Children With Early Childhood Caries: Randomized Controlled Trial.
This multisite, assessor-blinded randomized controlled trial evaluated a co-designed, 12-week SMS education and support program for parents of children aged 0 to 6 years with early childhood caries attending six public…
TIM3 Blockade with Hypomethylating Therapy Restores NK Cell and Cytotoxic CD4+ T-cell Activity in Patients with AML or MDS.
This phase Ib clinical trial examined immune changes in patients with AML or MDS treated with anti-TIM3 sabatolimab plus decitabine.
Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial.
This multicenter, open-label, blinded-endpoint randomized clinical trial compared intravenous tenecteplase before endovascular thrombectomy (EVT) with EVT alone in patients with moderate to severe basilar artery…
Examining individual and school-level predictors of positive attitudes towards condom use among adolescents in Tanzania: An exploratory analysis using hierarchical linear modeling.
This exploratory analysis examined individual and school-level correlates of attitudes toward condom use among Standard 7 adolescents in two Tanzanian districts.
Zanubrutinib, obinutuzumab, and venetoclax in CLL: long-term follow up, MRD kinetics, retreatment, T-cell profiling, and PKs.
This phase 2 trial evaluated an MRD-guided course of zanubrutinib, obinutuzumab, and venetoclax (BOVen) in treatment-naïve chronic lymphocytic leukemia, including assessment of zanubrutinib–venetoclax retreatment and…
Artificial Urinary Sphincter in Women: A Systematic Review of Clinical Outcomes and Technological Evolutions.
This systematic review examined clinical outcomes, surgical approaches, quality of life, and device developments for artificial urinary sphincter (AUS) implantation in women with stress urinary incontinence related to…
Fluid choice in pediatric diabetic ketoacidosis: a Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared balanced electrolyte solutions (BES) with 0.9% saline for fluid resuscitation in children with diabetic ketoacidosis (DKA), including randomized trials and observational…
Predictive Accuracy and Procedural Benefits of Software-Enhanced Flow-Diverter Planning: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed whether software simulations improve flow-diverter (FD) planning and procedural outcomes for intracranial aneurysms compared with physician planning.
Comparative Effectiveness of Non-Pharmacological Interventions for Management of Post-Orthodontic Pain: A Systematic Review and Network Meta-Analysis.
This systematic review and Bayesian network meta-analysis compared nine non-pharmacological approaches for orthodontic pain after fixed-appliance activation.
Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence: The ADHERE-ASCVD Randomized Clinical Trial.
The ADHERE-ASCVD pragmatic, health system-embedded randomized clinical trial tested adaptive digital outreach to prompt statin refills among adults with established ASCVD or high ASCVD risk and recent nonadherence.
Addition of probenecid to beta-lactam antibiotics in the treatment of skin and soft tissue infections: a systematic review.
This systematic review assessed the effectiveness and safety of adding probenecid to beta-lactam antibiotics for skin and soft tissue infections (SSTIs).
Singing-based interventions for motor and non-motor symptoms in Parkinson's disease: a systematic review.
This systematic review examined interventional studies of singing-based rehabilitation for motor and non-motor symptoms in people with Parkinson’s disease.
Effects of exercise interventions on leptin and ghrelin levels in middle-aged and older adults with overweight or obesity: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed randomized controlled trials of exercise interventions in middle-aged and older adults with overweight or obesity, examining changes in leptin and ghrelin.
Pain, sensory acceptability, and treatment compliance following cryotherapy and topical anesthetics in children: A randomized clinical trial.
This randomized clinical trial compared cryotherapy with topical anesthetics in 100 healthy children aged 7–10 years receiving their first dental treatment.
Multivessel Versus Single-Vessel Coronary Endarterectomy as an Adjunct to Coronary Artery Bypass Grafting: A Meta-Analysis of Short-Term Outcomes and Implications for Target-Vessel Selection.
This meta-analysis compared short-term outcomes after single-vessel versus multivessel coronary endarterectomy (CE) performed with coronary artery bypass grafting (CABG), using studies that reported both groups within…
Oncologic efficacy and safety of stereotactic body radiotherapy for oligometastatic non-small cell lung cancer: a systemic meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of stereotactic body radiotherapy (SBRT) for oligometastatic non-small cell lung cancer, including analyses by oligometastatic subtype and…
Epidemiological, etiological, and antifungal resistance patterns of vulvovaginal Candida spp. infections in Cameroon: A systematic review and meta-analysis.
This systematic review and meta-analysis pooled evidence from 34 studies of vulvovaginal Candida infection and vulvovaginal candidiasis (VVC) in Cameroon.
Radiomics performance to identify high-risk carotid artery plaques: a systematic review.
This systematic review assessed radiomics-based models for identifying high-risk carotid plaques. It included 28 studies involving 6,108 patients, 72.4% of whom were male.
A phase Ia first-in-human study of BPB-101, a novel trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in patients with locally advanced or metastatic solid tumors.
This phase Ia, multicenter, first-in-human dose-escalation study evaluated BPB-101, a trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in previously treated patients with advanced or metastatic solid…
Coronary artery calcification is not associated with survival in advanced gastric and gastroesophageal junction cancer: a secondary analysis of the EXPAND trial.
This secondary analysis of baseline CT images from the phase III EXPAND trial assessed whether coronary artery calcification (CAC) predicted overall survival in 785 patients with unresectable locally advanced or…
Efficacy of Lumateperone 42 mg in Major Depressive Disorder: Subgroup Analysis of a Phase 3 Randomized, Placebo-Controlled Trial.
This post hoc subgroup analysis of a phase 3, randomized, double-blind, placebo-controlled trial assessed adjunctive lumateperone 42 mg in adults with major depressive disorder and inadequate response to antidepressant…
Variation in recommendations for management of pediatric fever and neutropenia across databases and languages: A systematic review of clinical practice guidelines.
This systematic review and content analysis examined evidence-based clinical practice guidelines (CPGs) for fever and neutropenia in children, assessing how database indexing and publication language affected guideline…
Immunothrombosis Biomarkers and Multi-Omics Profiles After Successful Recanalization in Patients Receiving Ischemic Postconditioning: An Exploratory Analysis of the INSPIRE Trial.
This exploratory secondary analysis of the randomized INSPIRE trial examined 60 patients with ischemic stroke after successful endovascular thrombectomy recanalization.
Tetracaine hydrochloride gel delays and reduces catheter-related bladder discomfort after transurethral resection: a randomized controlled trial.
This randomized, single-blind trial compared tetracaine hydrochloride gel with standard lubricant in 130 patients undergoing transurethral resection.
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