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430 articles
November 202624
Effects of Polyphenols on Gut Health and Inflammation in Overweight and Obese Populations: A Systematic Review and Meta-analysis of Dose, Duration, and Food Matrix.
This systematic review and meta-analysis assessed polyphenol interventions and gut microbiota and inflammatory biomarkers in people with overweight or obesity, drawing on 32 randomized controlled trials.
The Role of Diet and Physical Activity in Gut Microbiota Modulation in Type 2 Diabetes Management: A Systematic Review of Clinical Trials.
This systematic review assessed clinical trials of dietary and physical activity interventions and gut microbiota in adults with type 2 diabetes or prediabetes.
The Safety, Pharmacokinetics, and Antiviral Activity of ABI-4334, A Novel Next-Generation Hepatitis B Capsid Assembly Modulator.
Two randomized Phase 1 studies assessed ABI-4334, a hepatitis B capsid assembly modulator, in healthy volunteers and participants with chronic hepatitis B (cHBV).
Physical Activity in Young Girls With Functional Abdominal Pain Disorders: Findings of a Randomized Controlled Intervention Trial With Dance and Yoga.
This randomized controlled trial assessed daily physical activity and abdominal pain in girls aged 9 to 13 years with functional abdominal pain disorders who participated in an 8-month dance and yoga intervention.
Predictors and prognostic impact of spontaneous portal vein thrombosis recanalization in cirrhosis: An individual patient data meta-analysis.
This individual patient data meta-analysis pooled cohort studies of patients with cirrhosis and portal vein thrombosis (PVT) who were not receiving anticoagulation.
Imaging-Based AI for Predicting Pathological Complete Response in Esophageal Cancer After Neoadjuvant Therapy: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed imaging-based AI models for predicting pathological complete response after neoadjuvant therapy for esophageal cancer, separating internal from external validation.
Polyamine Dysregulation in Metabolic Dysfunction-associated Steatotic Liver Disease: a Systematic Review of Human Observational Evidence.
This systematic review evaluated human observational evidence linking polyamines with MASLD severity and related hepatic or metabolic outcomes.
Differential effects of pea protein isolate, pea protein concentrate, and whey protein isolate supplementation on gut microbiota and metabolic markers in healthy adults: a 3-arm parallel randomised intervention.
This double-blind, three-arm randomised dietary intervention compared four weeks of pea protein concentrate (PPC), pea protein isolate (PPI), or whey protein isolate (WPI) supplementation in healthy adults.
Time-dependent efficacy of seven pharmacological regimens for ulcer healing and delayed bleeding prevention after gastric endoscopic submucosal dissection: A frequentist network meta-analysis.
This frequentist network meta-analysis compared seven pharmacological regimens for ulcer healing and prevention of delayed bleeding or perforation after gastric endoscopic submucosal dissection.
Triple immune impairment in an elderly patient with IgG4-AIP and MGUS complicated by dual severe infections over 3 years: A case report.
An 82-year-old man with IgG4-related autoimmune pancreatitis and IgGλ monoclonal gammopathy of undetermined significance had markedly elevated serum IgG4 and a monoclonal paraprotein at baseline.
Prognostic value of anti-gp210 antibodies in primary biliary cholangitis: A Systematic review and meta-analysis.
This systematic review and meta-analysis pooled evidence from 12 records examining the prognostic significance of anti-gp210 antibodies in people with primary biliary cholangitis (PBC).
Synchronous hepatocellular carcinoma and nasopharyngeal carcinoma in a patient with chronic hepatitis B: A case report and literature review.
A 63-year-old Chinese man with chronic hepatitis B was found on routine screening to have a liver mass and reported nasal obstruction.
Sirolimus-induced improvement of immune dysregulation associated hepatosplenomegaly in common variable immunodeficiency: a case-based review.
A 50-year-old woman with common variable immunodeficiency (CVID), treated with regular intravenous immunoglobulin replacement, developed progressive hepatosplenomegaly, cytopenias, abdominal enlargement, dyspnea…
Resistance training and protein supplementation in patients with incurable gastroesophageal cancer: a randomized feasibility trial.
This open-label, parallel-group randomized feasibility trial assessed resistance training plus protein supplementation during first-line chemotherapy in patients with incurable gastroesophageal cancer.
Plozasiran for Severe Hypertriglyceridemia and Risk of Pancreatitis.
Two double-blind, placebo-controlled randomized trials evaluated plozasiran in 757 adults with severe hypertriglyceridemia.
Clinical Evidence for Adding Chaiqin Chengqi Decoction to Acute Pancreatitis Care: A Systematic Review and Meta-analysis of Randomized Trials.
This systematic review and meta-analysis assessed randomized trials of Chaiqin Chengqi Decoction (CQCQD) added to conventional care for acute pancreatitis. Nineteen trials involving 1,824 participants were included.
Resolution of Severe Jaundice Following Hepatic Artery Infusion of Bevacizumab and 5-Fluorouracil With Oral Regorafenib in Metastatic Colorectal Cancer：A Case Report.
A patient with sigmoid colon cancer and recurrent liver metastases, previously treated with surgery, systemic chemotherapy, transcatheter arterial chemoembolization, and radiotherapy, presented with severe jaundice.
Severe Atherogenic Dyslipidemia in Ataxia-Telangiectasia Despite Cachexia: Mechanistic Insights into Mitochondrial Dysfunction.
A 25-year-old woman with genetically confirmed ataxia-telangiectasia and extreme underweight (body mass index 12.5 kg/m²) developed severe mixed atherogenic dyslipidemia despite modest dietary fat intake and no…
Rifamycin use and gut microbial antibiotic resistance genes in cirrhosis: Results from a double-blind, placebo-controlled clinical trial.
This double-blind, placebo-controlled randomized trial assessed changes in gut antimicrobial resistance genes (ARGs) with rifamycin SV MMX (RiVM) in patients with compensated cirrhosis.
Submucosal Tunnel Endoscopic Resection of a Gastric Schwannoma Mimicking a Submucosal Tumor.
A 73-year-old woman with recurrent abdominal distension was found on esophagogastroduodenoscopy to have an 8.2 mm submucosal lesion in the gastric body.
Colonoscopy surveillance after colorectal cancer surgery: meta-analysis.
This systematic review and meta-analysis examined randomized trials comparing follow-up protocols with versus without colonoscopy within 5 years after colorectal cancer surgery.
Cesarean Delivery After Multiple Prior Intraperitoneal Surgeries: A Case Report in a Patient With Crohn Disease.
A 25-year-old woman with Crohn disease in sustained remission had an uncomplicated pregnancy after in vitro fertilization. Her history included five intraperitoneal operations, including bilateral hemicolectomy…
Effect of Food on the Pharmacokinetics, Pharmacodynamics, and Safety of Zastaprazan, a Potassium-Competitive Acid Blocker, in Healthy Participants.
This randomized, open-label, two-period crossover phase 1 study assessed food effects on zastaprazan pharmacokinetics, pharmacodynamics, and safety in 24 healthy participants given a single 20 mg dose.
Clinical significance of isolated periappendiceal red patch in ulcerative colitis: A systematic review, meta-analysis, and meta-regression.
This systematic review and meta-analysis examined whether an isolated periappendiceal red patch (PARP) is associated with disease extent or outcomes in ulcerative colitis.
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